Prolonged antifungal effects of clotrimazole-containing mucoadhesive thermosensitive gels on vaginitis

Jung Yun Chang, Yu Kyoung Oh, Hak Soo Kong, Eun Jung Kim, Dong Deuk Jang, Ki Taek Nam, Chong Kook Kim

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153 Citations (Scopus)


To develop more effective treatment for vaginal candidasis, clotrimazole (CT) was formulated in mucoadhesive thermosensitive gels (MTG). Several MTG formulations composed of poloxamers (P) 407, 188, and polycarbophil (PC) were prepared. P188 and PC increased the mucoadhesiveness but reduced the syringebility of liquid forms of the gels. Based on the balance between the mucoadhesiveness and syringebility, MTG composed of P407/P188/PC (15/15/0.2 or 15/20/0.2) were further studied. Of the two MTG, the formulation with 15% of P188 gelled at higher temperature and revealed lower elastic modulus. In vitro, sustained release of CT from MTG was observed. In vivo antifungal activity of CT, tested against Candida albicans vaginitis in female rats, was significantly prolonged after vaginal delivery using MTG. At 10 days post-dose, the c.f.u. of C. albicans was more than 104-fold decreased in MTG-treated groups. Moreover, the vaginal delivery of CT in MTG enhanced the viability of epithelial cells without affecting the morphology of vaginal mucosa. These results indicate that CT-containing vaginal MTG might be further developed for safe, convenient, and effective treatment of vaginal candidasis with reduced dosing interval.

Original languageEnglish
Pages (from-to)39-50
Number of pages12
JournalJournal of Controlled Release
Issue number1
Publication statusPublished - 2002 Jul 18

Bibliographical note

Funding Information:
This work was supported by a grant from the Korea Science and Engineering Foundation (KOSEF 1999-2-21700-001-3).

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science


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