Proliferation effects on hair growth of compounds isolated from the bark of Dalbergia oliveri

Seon Ju Park, Nguyen Xuan Nhiem, Bui Huu Tai, Hoang Le Tuan Anh, Seok Hyun Oh, Jong Hyuk Sung, Nanyoung Kim, Guijae Yoo, Jun Hyung Park, Hee Jae Kwak, Pham Thanh Loan, Seung Hyun Kim, Phan Van Kiem

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


One new isoflavane, 7,4′-dihydroxy-isoflavanquinone (1), together with ten known compounds (2-11) were isolated from the bark of Dalbergia oliveri Prain. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 1D and 2D NMR and CD spectroscopic data. Using a cell proliferation assay, the isolated compounds were evaluated for their proliferation effects on hair growth. (3R)-5′-Methoxyvestitol (2) and (6aR,11aR)-3,8-dihydroxy-9-methoxypterocarpan (10) significantly increased the proliferation of immortalized dermal papilla cells (iDPC).

Original languageEnglish
Pages (from-to)1729-1730
Number of pages2
JournalNatural product communications
Issue number11
Publication statusPublished - 2017 Nov

Bibliographical note

Funding Information:
This research was supported by the National Research Foundation of Korea (NRF) grant [NRF-2016R1A2B4006742] funded by the Ministry of Education, Science and Technology, Republic of Korea.

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine


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