TY - JOUR
T1 - Progress Identifying and Analyzing the Human Proteome
T2 - 2021 Metrics from the HUPO Human Proteome Project
AU - Omenn, Gilbert S.
AU - Lane, Lydie
AU - Overall, Christopher M.
AU - Paik, Young Ki
AU - Cristea, Ileana M.
AU - Corrales, Fernando J.
AU - Lindskog, Cecilia
AU - Weintraub, Susan
AU - Roehrl, Michael H.A.
AU - Liu, Siqi
AU - Bandeira, Nuno
AU - Srivastava, Sudhir
AU - Chen, Yu Ju
AU - Aebersold, Ruedi
AU - Moritz, Robert L.
AU - Deutsch, Eric W.
N1 - Publisher Copyright:
© 2021 American Chemical Society.
PY - 2021/12/3
Y1 - 2021/12/3
N2 - The 2021 Metrics of the HUPO Human Proteome Project (HPP) show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 »357 (92.8%) of the 19 »778 predicted proteins coded in the human genome, a gain of 483 since 2020 from reports throughout the world reanalyzed by the HPP. Conversely, the number of neXtProt PE2, PE3, and PE4 missing proteins has been reduced by 478 to 1421. This represents remarkable progress on the proteome parts list. The utilization of proteomics in a broad array of biological and clinical studies likewise continues to expand with many important findings and effective integration with other omics platforms. We present highlights from the Immunopeptidomics, Glycoproteomics, Infectious Disease, Cardiovascular, Musculo-Skeletal, Liver, and Cancers B/D-HPP teams and from the Knowledgebase, Mass Spectrometry, Antibody Profiling, and Pathology resource pillars, as well as ethical considerations important to the clinical utilization of proteomics and protein biomarkers.
AB - The 2021 Metrics of the HUPO Human Proteome Project (HPP) show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 »357 (92.8%) of the 19 »778 predicted proteins coded in the human genome, a gain of 483 since 2020 from reports throughout the world reanalyzed by the HPP. Conversely, the number of neXtProt PE2, PE3, and PE4 missing proteins has been reduced by 478 to 1421. This represents remarkable progress on the proteome parts list. The utilization of proteomics in a broad array of biological and clinical studies likewise continues to expand with many important findings and effective integration with other omics platforms. We present highlights from the Immunopeptidomics, Glycoproteomics, Infectious Disease, Cardiovascular, Musculo-Skeletal, Liver, and Cancers B/D-HPP teams and from the Knowledgebase, Mass Spectrometry, Antibody Profiling, and Pathology resource pillars, as well as ethical considerations important to the clinical utilization of proteomics and protein biomarkers.
KW - Biology and Disease-HPP (B/D-HPP)
KW - Chromosome-centric HPP (C-HPP)
KW - Human Protein Atlas
KW - Human Proteome Project (HPP)
KW - Mass Spectrometry Interactive Virtual Environment (MassIVE)
KW - PeptideAtlas
KW - missing proteins (MP)
KW - neXtProt protein existence (PE) metrics
KW - non-MS PE1 proteins
KW - uncharacterized protein existence 1 (uPE1)
UR - http://www.scopus.com/inward/record.url?scp=85118767127&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85118767127&partnerID=8YFLogxK
U2 - 10.1021/acs.jproteome.1c00590
DO - 10.1021/acs.jproteome.1c00590
M3 - Review article
C2 - 34670092
AN - SCOPUS:85118767127
SN - 1535-3893
VL - 20
SP - 5227
EP - 5240
JO - Journal of Proteome Research
JF - Journal of Proteome Research
IS - 12
ER -
