Progress and Future Direction of Chromosome-Centric Human Proteome Project

Young Ki Paik, Christopher M. Overall, Eric W. Deutsch, Jennifer E. Van Eyk, Gilbert S. Omenn

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)


This special issue of JPR celebrates the fifth anniversary of the Chromosome-Centric Human Proteome Project (C-HPP). We present 27 manuscripts in four categories: (i) Metrics of Progress and Resources, (ii) Missing Protein Detection and Validation, (iii) Analytical Methods and Quality Assessment, and (iv) Protein Functions and Disease. We briefly introduce key messages from each paper, mostly from C-HPP teams and some from the Biology and Disease-driven HPP. From the first few months of the C-HPP NeXt-MP50 Missing Proteins Challenge, authors report 73 missing protein detections that meet the HPP guidelines using several novel approaches. Finally, we discuss future directions.

Original languageEnglish
Pages (from-to)4253-4258
Number of pages6
JournalJournal of Proteome Research
Issue number12
Publication statusPublished - 2017 Dec 1

Bibliographical note

Funding Information:
This work was supported by grants from the Korean Ministry of Health and Welfare (HI13C2098-International Consortium Project and HI16C0257 to Y.-K.P.) and from the U.S. National Institutes of Health (P30ES017885-01A1 and U24CA210967 to G.S.O.)

Publisher Copyright:
© 2017 American Chemical Society.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Chemistry(all)


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