TY - JOUR
T1 - Prognostic value of nuclear DNA quantification and cyclin A expression in epithelial ovarian carcinoma
AU - Yoon, Bo Sung
AU - Kim, Young Tae
AU - Kim, Sunghoon
AU - Lee, Chong Seung
AU - Kim, Jae Wook
AU - Kim, Jae Hoon
AU - Kim, Sang Wun
AU - Cho, Nam Hoon
PY - 2008/1
Y1 - 2008/1
N2 - Objective: To investigate the correlation of DNA ploidy, S-phase fraction (SPF) and the expression of cyclin A to the clinical prognostic factors in patients with epithelial ovarian cancer. Study design: A prospective analysis was performed on 46 ovarian tumor patients. The DNA ploidy and SPF were determined by flow cytometry and the expression of cyclin A was measured by immunohistochemical staining. Results: Compared with benign and borderline tumors, the malignant tumors expressed higher levels of cyclin A (P = 0.007), more aneuploid cells (P = 0.018) and higher SPF (P = 0.015). With regard to DNA ploidy and the clinical prognostic factors, aneuploid cells increased with tumor grade (P = 0.011), the disease stage (P = 0.009) and residual volume (P = 0.001). When residual tumor was more than 2 cm, the expression of cyclin A was increased (P = 0.043). Three-year survival was low for patients with tumors expressing cyclin A in over 10% of cells (P = 0.003). Conclusions: The data suggest that the assessment of the DNA ploidy, SPF and the expression of cyclin A may provide important information for predicting the prognosis of epithelial ovarian cancer.
AB - Objective: To investigate the correlation of DNA ploidy, S-phase fraction (SPF) and the expression of cyclin A to the clinical prognostic factors in patients with epithelial ovarian cancer. Study design: A prospective analysis was performed on 46 ovarian tumor patients. The DNA ploidy and SPF were determined by flow cytometry and the expression of cyclin A was measured by immunohistochemical staining. Results: Compared with benign and borderline tumors, the malignant tumors expressed higher levels of cyclin A (P = 0.007), more aneuploid cells (P = 0.018) and higher SPF (P = 0.015). With regard to DNA ploidy and the clinical prognostic factors, aneuploid cells increased with tumor grade (P = 0.011), the disease stage (P = 0.009) and residual volume (P = 0.001). When residual tumor was more than 2 cm, the expression of cyclin A was increased (P = 0.043). Three-year survival was low for patients with tumors expressing cyclin A in over 10% of cells (P = 0.003). Conclusions: The data suggest that the assessment of the DNA ploidy, SPF and the expression of cyclin A may provide important information for predicting the prognosis of epithelial ovarian cancer.
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U2 - 10.1016/j.ejogrb.2006.10.008
DO - 10.1016/j.ejogrb.2006.10.008
M3 - Article
C2 - 17157431
AN - SCOPUS:37549035944
SN - 0028-2243
VL - 136
SP - 110
EP - 115
JO - European Journal of Obstetrics and Gynecology and Reproductive Biology
JF - European Journal of Obstetrics and Gynecology and Reproductive Biology
IS - 1
ER -
