Prognostic implications of the immunophenotype in biphenotypic acute leukemia

Je Hwan Lee; Yoo Hong Min; Chul Won Chung; Byoung Kook Kim; Hwi Joong Yoon; Deog Yeon Jo; Ho Jin Shin; Soo Mee Bang; Jong Ho Won; Dae Young Zang; Hyeoung Joon Kim; Hyun Sook Chi; Kyoo Hyung Lee; June Won Cheong; Jin Seok Kim; Sun Hee Kim; Seonyang Park; Su Yon Park; Joo Seop Chung; Jae Hoon Lee; Chan Jeoung Park

doi:10.1080/10428190701843247

Prognostic implications of the immunophenotype in biphenotypic acute leukemia

Je Hwan Lee, Yoo Hong Min, Chul Won Chung, Byoung Kook Kim, Hwi Joong Yoon, Deog Yeon Jo, Ho Jin Shin, Soo Mee Bang, Jong Ho Won, Dae Young Zang, Hyeoung Joon Kim, Hyun Sook Chi, Kyoo Hyung Lee, June Won Cheong, Jin Seok Kim, Sun Hee Kim, Seonyang Park, Su Yon Park, Joo Seop Chung, Jae Hoon LeeChan Jeoung Park

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

The present study retrospectively analyzed clinicopathological and clinical data from 43 adult patients with biphenotypic acute leukemia (BAL) from 11 Korean institutes. The incidence of BAL was 2.1% among acute leukemias. In terms of immunophenotype, 31 patients had myeloid plus B-lymphoid (M + B), 10 had myeloid plus T-lymphoid (M + T), one had myeloid plus B-lymphoid plus T-lymphoid (M + B + T), and one had B-lymphoid plus T-lymphoid (B + T). Patients with M + T phenotype had significantly lower CR rate (55.6% vs. 88.0%, P = 0.039) and lower overall survival (0% vs. 33.9% at 5 years, P = 0.028) than those with M + B phenotype. Our results suggest that immunophenotype has prognostic implications in adult patients with BAL.

Original language	English
Pages (from-to)	700-709
Number of pages	10
Journal	Leukemia and Lymphoma
Volume	49
Issue number	4
DOIs	https://doi.org/10.1080/10428190701843247
Publication status	Published - 2008 Apr

All Science Journal Classification (ASJC) codes

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/10428190701843247

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Lee, J. H., Min, Y. H., Chung, C. W., Kim, B. K., Yoon, H. J., Jo, D. Y., Shin, H. J., Bang, S. M., Won, J. H., Zang, D. Y., Kim, H. J., Chi, H. S., Lee, K. H., Cheong, J. W., Kim, J. S., Kim, S. H., Park, S., Park, S. Y., Chung, J. S., ... Park, C. J. (2008). Prognostic implications of the immunophenotype in biphenotypic acute leukemia. Leukemia and Lymphoma, 49(4), 700-709. https://doi.org/10.1080/10428190701843247

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title = "Prognostic implications of the immunophenotype in biphenotypic acute leukemia",

abstract = "The present study retrospectively analyzed clinicopathological and clinical data from 43 adult patients with biphenotypic acute leukemia (BAL) from 11 Korean institutes. The incidence of BAL was 2.1% among acute leukemias. In terms of immunophenotype, 31 patients had myeloid plus B-lymphoid (M + B), 10 had myeloid plus T-lymphoid (M + T), one had myeloid plus B-lymphoid plus T-lymphoid (M + B + T), and one had B-lymphoid plus T-lymphoid (B + T). Patients with M + T phenotype had significantly lower CR rate (55.6% vs. 88.0%, P = 0.039) and lower overall survival (0% vs. 33.9% at 5 years, P = 0.028) than those with M + B phenotype. Our results suggest that immunophenotype has prognostic implications in adult patients with BAL.",

author = "Lee, {Je Hwan} and Min, {Yoo Hong} and Chung, {Chul Won} and Kim, {Byoung Kook} and Yoon, {Hwi Joong} and Jo, {Deog Yeon} and Shin, {Ho Jin} and Bang, {Soo Mee} and Won, {Jong Ho} and Zang, {Dae Young} and Kim, {Hyeoung Joon} and Chi, {Hyun Sook} and Lee, {Kyoo Hyung} and Cheong, {June Won} and Kim, {Jin Seok} and Kim, {Sun Hee} and Seonyang Park and Park, {Su Yon} and Chung, {Joo Seop} and Lee, {Jae Hoon} and Park, {Chan Jeoung}",

year = "2008",

month = apr,

doi = "10.1080/10428190701843247",

language = "English",

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Lee, JH, Min, YH, Chung, CW, Kim, BK, Yoon, HJ, Jo, DY, Shin, HJ, Bang, SM, Won, JH, Zang, DY, Kim, HJ, Chi, HS, Lee, KH, Cheong, JW, Kim, JS, Kim, SH, Park, S, Park, SY, Chung, JS, Lee, JH & Park, CJ 2008, 'Prognostic implications of the immunophenotype in biphenotypic acute leukemia', Leukemia and Lymphoma, vol. 49, no. 4, pp. 700-709. https://doi.org/10.1080/10428190701843247

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AU - Lee, Je Hwan

AU - Min, Yoo Hong

AU - Chung, Chul Won

AU - Kim, Byoung Kook

AU - Yoon, Hwi Joong

AU - Jo, Deog Yeon

AU - Shin, Ho Jin

AU - Bang, Soo Mee

AU - Won, Jong Ho

AU - Zang, Dae Young

AU - Kim, Hyeoung Joon

AU - Chi, Hyun Sook

AU - Lee, Kyoo Hyung

AU - Cheong, June Won

AU - Kim, Jin Seok

AU - Kim, Sun Hee

AU - Park, Seonyang

AU - Park, Su Yon

AU - Chung, Joo Seop

AU - Lee, Jae Hoon

AU - Park, Chan Jeoung

PY - 2008/4

Y1 - 2008/4

N2 - The present study retrospectively analyzed clinicopathological and clinical data from 43 adult patients with biphenotypic acute leukemia (BAL) from 11 Korean institutes. The incidence of BAL was 2.1% among acute leukemias. In terms of immunophenotype, 31 patients had myeloid plus B-lymphoid (M + B), 10 had myeloid plus T-lymphoid (M + T), one had myeloid plus B-lymphoid plus T-lymphoid (M + B + T), and one had B-lymphoid plus T-lymphoid (B + T). Patients with M + T phenotype had significantly lower CR rate (55.6% vs. 88.0%, P = 0.039) and lower overall survival (0% vs. 33.9% at 5 years, P = 0.028) than those with M + B phenotype. Our results suggest that immunophenotype has prognostic implications in adult patients with BAL.

AB - The present study retrospectively analyzed clinicopathological and clinical data from 43 adult patients with biphenotypic acute leukemia (BAL) from 11 Korean institutes. The incidence of BAL was 2.1% among acute leukemias. In terms of immunophenotype, 31 patients had myeloid plus B-lymphoid (M + B), 10 had myeloid plus T-lymphoid (M + T), one had myeloid plus B-lymphoid plus T-lymphoid (M + B + T), and one had B-lymphoid plus T-lymphoid (B + T). Patients with M + T phenotype had significantly lower CR rate (55.6% vs. 88.0%, P = 0.039) and lower overall survival (0% vs. 33.9% at 5 years, P = 0.028) than those with M + B phenotype. Our results suggest that immunophenotype has prognostic implications in adult patients with BAL.

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Prognostic implications of the immunophenotype in biphenotypic acute leukemia

Abstract

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