TY - JOUR
T1 - Prognostic effect of perioperative change of serum carcinoembryonic antigen level
T2 - A useful tool for detection of systemic recurrence in rectal cancer
AU - Park, Yoon Ah
AU - Kang, Young Lee
AU - Nam, Kyu Kim
AU - Seung, Hyuk Baik
AU - Seung, Kook Sohn
AU - Chang, Whan Cho
N1 - Funding Information:
The authors thank Scott Butler, MD, for his editorial comments. This study was supported by Yonsei University Research Fund of 2002.
PY - 2006/5
Y1 - 2006/5
N2 - Background: The prognosis of patients even with the same stage of rectal cancer varies widely. We analyzed the capability of perioperative change of serum carcinoembryonic antigen (CEA) level for predicting recurrence and survival in rectal cancer patients. Methods: We reviewed 631 patients who underwent potentially curative resection for stage II or III rectal cancer. Patients were categorized into three groups according to their serum CEA concentrations on the seventh day before and on the seventh day after surgery: group A, normal CEA level (≤5 ng/mL) in both periods; group B, increased preoperative and normal postoperative CEA; and group C, continuously increased CEA in both periods. The prognostic relevance of the CEA group was investigated by analyses of recurrence patterns and survival. Results: Stage III patients showed higher systemic recurrence (P = .001) and worse 5-year survival rates (P < .0001) for group C than for groups A and B. On multivariate analysis, the CEA group was a significant predictor for recurrence (P < .001; relative risk, 2.740; 95% confidence interval, 1.677-4.476) and survival (P = .001; relative risk, 2.174; 95% confidence interval, 1.556-3.308). Conclusions: The perioperative serum CEA change was a useful prognostic indicator to predict for systemic recurrence and survival in stage III rectal cancer patients.
AB - Background: The prognosis of patients even with the same stage of rectal cancer varies widely. We analyzed the capability of perioperative change of serum carcinoembryonic antigen (CEA) level for predicting recurrence and survival in rectal cancer patients. Methods: We reviewed 631 patients who underwent potentially curative resection for stage II or III rectal cancer. Patients were categorized into three groups according to their serum CEA concentrations on the seventh day before and on the seventh day after surgery: group A, normal CEA level (≤5 ng/mL) in both periods; group B, increased preoperative and normal postoperative CEA; and group C, continuously increased CEA in both periods. The prognostic relevance of the CEA group was investigated by analyses of recurrence patterns and survival. Results: Stage III patients showed higher systemic recurrence (P = .001) and worse 5-year survival rates (P < .0001) for group C than for groups A and B. On multivariate analysis, the CEA group was a significant predictor for recurrence (P < .001; relative risk, 2.740; 95% confidence interval, 1.677-4.476) and survival (P = .001; relative risk, 2.174; 95% confidence interval, 1.556-3.308). Conclusions: The perioperative serum CEA change was a useful prognostic indicator to predict for systemic recurrence and survival in stage III rectal cancer patients.
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U2 - 10.1245/ASO.2006.03.090
DO - 10.1245/ASO.2006.03.090
M3 - Review article
C2 - 16538413
AN - SCOPUS:33645876797
SN - 1068-9265
VL - 13
SP - 645
EP - 650
JO - Annals of surgical oncology
JF - Annals of surgical oncology
IS - 5
ER -
