Probabilistic evaluation of surface-enhanced localized surface plasmon resonance biosensing

Heejin Yang, Wonju Lee, Taewon Hwang, Donghyun Kim

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


In this paper, we investigate detection characteristics of localized surface plasmon resonance biosensing based on a probabilistic Poisson distribution of target molecules. The model uses random nanoislands for localization of near-fields in three detection scenarios of non-specific, non-colocalized, and colocalized detection. Optical signatures were found to increase monotonically with target concentration and size regardless of the detection scenarios. The signatures were largest in colocalized detection of target interactions to localized fields, followed by non-colocalized and non-specific detection. The confidence interval was the narrowest in the colocalized detection due to the increased spatial certainty by localization. Based on the relative confidence interval, it was found that limit of detection can be enhanced by more than four orders of magnitude through colocalization.

Original languageEnglish
Pages (from-to)28412-28426
Number of pages15
JournalOptics Express
Issue number23
Publication statusPublished - 2014 Nov 17

Bibliographical note

Publisher Copyright:
©2014 Optical Society of America

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics


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