Preventive approach for overcoming dementia

Hee Yang Lee, Da Won Kim, Woogyeong Lee, Hye Yun Kim, Young Soo Kim

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)


Dementia is used as a general term to describe chronic disorders of mental processes caused by the deterioration of cognitive functions to the extent that one’s ability to perform daily activities is impaired. Currently, age is known to be the main risk factor for dementia, suggesting that the risk of being diagnosed with dementia significantly increases later in one’s life. Therefore, there are two approaches one can take when confronting dementia: to cure it when it occurs in late adulthood or to prevent the onset of symptoms beforehand. Recently, the latter strategy of delaying and preventing Alzheimer’s disease, the most prevalent form and most studied type of dementia, through both pharmaceutical and nonpharmaceutical interventions is becoming increasingly recognized. In this review, we discuss studies conducted in various fields that addresses nonpharmaceutical lifestyle interventions, including diet, physical activity, cognitive stimulation, and social engagement, and their effects in preventing and inhibiting dementia.

Original languageEnglish
Pages (from-to)647-657
Number of pages11
JournalArchives of pharmacal research
Issue number8
Publication statusPublished - 2019 Aug 1

Bibliographical note

Funding Information:
This work was supported by National Research Foundation (Basic Science Research Program NRF-2018R1A6A1A03023718, NRF-2018R1D1A1B07048857 and Original Technology Research Program for Brain Science NRF-2018M3C7A1021858), and Yonsei University (Grant No. 2018-22-0022).

Publisher Copyright:
© 2019, The Pharmaceutical Society of Korea.

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry


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