Prevalence of retinal nerve fiber layer defects: The Korea National Health and Nutrition Examination Survey 2008–2012

Epidemiologic Survey Committee of the Korean Ophthalmologic Society

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3 Citations (Scopus)


Purpose: To investigate the prevalence and associated factors of retinal nerve fiber layer defects (RNFLDs) in a Korean population. Methods: The Korea National Health and Nutrition Examination Survey (KNHANES) is a population-based study using a complex, stratified, multistage, probability-cluster survey. We performed a review of 2008–2012 data from the KNHANES. Two masked ophthalmologists evaluated fundus photography to detect RNFLDs. All participants underwent ocular and systemic evaluations. Results: A total of 28,637 subjects aged 19 years with at least one evaluable fundus photograph were enrolled. The estimated prevalence of RNFLDs in this Korean population was 4.8% (95% confidence interval, 4.4%–5.3%). The estimated percentages of glaucomatous RNFLD and non-glaucomatous RNFLD subjects were 34.4% and 65.6%, respectively. In a multivariate analysis, the prevalence of RNFLDs was significantly associated with older age (P < 0.001), male gender (P = 0.047), glycosylated hemoglobin (P = 0.048), disc hemorrhage (P = 0.016), ISNT rule (P < 0.001), and vertical cup to disc ratio (P < 0.001). Conclusions: The prevalence of RNFLDs in a large Korean population-based sample with a minimum age of 19 years was 4.8%. RNFLD prevalence was associated with old age, male gender, glycosylated hemoglobin, disc hemorrhage, and glaucomatous optic disc.

Original languageEnglish
Article numbere0186032
JournalPloS one
Issue number10
Publication statusPublished - 2017 Oct

Bibliographical note

Publisher Copyright:
© 2017 Na et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

All Science Journal Classification (ASJC) codes

  • General


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