TY - JOUR
T1 - Prevalence of inducible clindamycin resistance in staphylococcal isolates at a Korean Tertiary Care Hospital
AU - Lim, Hwan Sub
AU - Lee, Hyukmin
AU - Roh, Kyoung Ho
AU - Yum, Jong Hwa
AU - Yong, Dongeun
AU - Lee, Kyungwon
AU - Chong, Yunsop
PY - 2006/8
Y1 - 2006/8
N2 - Clindamycin resistance in Staphylococcus species can be either constitutive or inducible. Inducible resistance cannot be detected by the conventional antimicrobial susceptibility test. In this study, we determined the prevalence of inducible clindamycin resistance in staphylococcal isolates at a Korean tertiary care hospital. Between February and September 2004, 1,519 isolates of Staphylococcus aureus and 1.043 isolates of coagulase-negative staphylococci (CNS) were tested for inducible resistance by the D-zone test. Overall, 17%, of MRSA, 84% of MSSA, 37% of MRCNS, and 70% of MSCNS were susceptible to clindamycin. Of the erythromycin non-susceptible, clindamycin-susceptible isolates, 32%, of MRSA, 35% of MSSA, 90%, of MRCNS, and 94% of MSCNS had inducible clindamycin resistance. Inducible clindamycin resistance in staphylococci was highly prevalent in Korea. This study indicates importance of the D-zone test in detecting inducible clindamycin resistance in staphylococci to aid in the optimal treatment of patients.
AB - Clindamycin resistance in Staphylococcus species can be either constitutive or inducible. Inducible resistance cannot be detected by the conventional antimicrobial susceptibility test. In this study, we determined the prevalence of inducible clindamycin resistance in staphylococcal isolates at a Korean tertiary care hospital. Between February and September 2004, 1,519 isolates of Staphylococcus aureus and 1.043 isolates of coagulase-negative staphylococci (CNS) were tested for inducible resistance by the D-zone test. Overall, 17%, of MRSA, 84% of MSSA, 37% of MRCNS, and 70% of MSCNS were susceptible to clindamycin. Of the erythromycin non-susceptible, clindamycin-susceptible isolates, 32%, of MRSA, 35% of MSSA, 90%, of MRCNS, and 94% of MSCNS had inducible clindamycin resistance. Inducible clindamycin resistance in staphylococci was highly prevalent in Korea. This study indicates importance of the D-zone test in detecting inducible clindamycin resistance in staphylococci to aid in the optimal treatment of patients.
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U2 - 10.3349/ymj.2006.47.4.480
DO - 10.3349/ymj.2006.47.4.480
M3 - Article
C2 - 16941736
AN - SCOPUS:33748305675
SN - 0513-5796
VL - 47
SP - 480
EP - 484
JO - Yonsei Medical Journal
JF - Yonsei Medical Journal
IS - 4
ER -