TY - JOUR
T1 - Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea
AU - Jeong, Hwan Shin
AU - Hee, Jung Jung
AU - Hye, Ran Kim
AU - Jeong, Joseph
AU - Seok, Hoon Jeong
AU - Kim, Sunjoo
AU - Eun, Yup Lee
AU - Jeong, Nyeo Lee
AU - Chulhun, Ludgerus Chang
PY - 2007/7
Y1 - 2007/7
N2 - The genes erm(B), mef(A), and both erm(B) and mef(A) were identified in 42.6, 10.1, and 47.3%, respectively, of the erythromycin-resistant Streptococcus pneumoniae isolates. Of the strains, 3.8% were nonsusceptible to levofioxacin and had 1 to 6 amino acid changes in the quinolone resistance-determining region, including a new mutation, Asn94Ser, in the product of parC. Levofioxacin with reserpine was highly specific for efflux screening.
AB - The genes erm(B), mef(A), and both erm(B) and mef(A) were identified in 42.6, 10.1, and 47.3%, respectively, of the erythromycin-resistant Streptococcus pneumoniae isolates. Of the strains, 3.8% were nonsusceptible to levofioxacin and had 1 to 6 amino acid changes in the quinolone resistance-determining region, including a new mutation, Asn94Ser, in the product of parC. Levofioxacin with reserpine was highly specific for efflux screening.
UR - http://www.scopus.com/inward/record.url?scp=34447258125&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34447258125&partnerID=8YFLogxK
U2 - 10.1128/AAC.00107-07
DO - 10.1128/AAC.00107-07
M3 - Article
C2 - 17502407
AN - SCOPUS:34447258125
SN - 0066-4804
VL - 51
SP - 2625
EP - 2627
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 7
ER -
