TY - JOUR
T1 - Prevalence and diversity of carbapenemases among imipenem-nonsusceptible Acinetobacter isolates in Korea
T2 - Emergence of a novel OXA-182
AU - Kim, Chang Ki
AU - Lee, Yangsoon
AU - Lee, Hyukmin
AU - Woo, Gun Jo
AU - Song, Wonkeun
AU - Kim, Mi Na
AU - Lee, Wee Gyo
AU - Jeong, Seok Hoon
AU - Lee, Kyungwon
AU - Chong, Yunsop
N1 - Funding Information:
This study was supported in part by grant S-07-02-2-ABI-174-0-T from the Korea Food and Drug Administration in 2007, Republic of Korea.
PY - 2010/12
Y1 - 2010/12
N2 - Increase in multidrug-resistant Acinetobacter poses a serious problem in Korea. In this study, 190 imipenem (IPM)-nonsusceptible (NS) Acinetobacter isolates from 12 Korean hospitals in 2007 were used to determine species, prevalence, and antimicrobial susceptibility of OXA carbapenemase- and metallo-?-lactamase (MBL)-producing isolates. blaOXA-23-like and ISAba1-asssociated blaOXA-51-like genes were detected in 80% and 12% of 178 IPM-NS Acinetobacter baumannii isolates, respectively. A novel blaOXA-182 was detected in 12 IPM-NS A. baumannii isolates. Twelve out of 14 MBL-producing isolates were non-baumannii Acinetobacter. A. baumannii isolates with OXA carbapenemase were more often resistant to aminoglycosides, ciprofloxacin, and tigecycline than non-baumannii Acinetobacter isolates with MBL. Identical pulsed- field gel electrophoresis patterns were observed in 89% of A. baumannii isolates with blaOXA-23-like gene. In conclusion, extremely rapid increase of IPM-NS A. baumannii in previous Korean studies was mainly due to clonal spread of OXA-23-producing A. baumannii isolates. A novel OXA-182 emerged in Korea.
AB - Increase in multidrug-resistant Acinetobacter poses a serious problem in Korea. In this study, 190 imipenem (IPM)-nonsusceptible (NS) Acinetobacter isolates from 12 Korean hospitals in 2007 were used to determine species, prevalence, and antimicrobial susceptibility of OXA carbapenemase- and metallo-?-lactamase (MBL)-producing isolates. blaOXA-23-like and ISAba1-asssociated blaOXA-51-like genes were detected in 80% and 12% of 178 IPM-NS Acinetobacter baumannii isolates, respectively. A novel blaOXA-182 was detected in 12 IPM-NS A. baumannii isolates. Twelve out of 14 MBL-producing isolates were non-baumannii Acinetobacter. A. baumannii isolates with OXA carbapenemase were more often resistant to aminoglycosides, ciprofloxacin, and tigecycline than non-baumannii Acinetobacter isolates with MBL. Identical pulsed- field gel electrophoresis patterns were observed in 89% of A. baumannii isolates with blaOXA-23-like gene. In conclusion, extremely rapid increase of IPM-NS A. baumannii in previous Korean studies was mainly due to clonal spread of OXA-23-producing A. baumannii isolates. A novel OXA-182 emerged in Korea.
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U2 - 10.1016/j.diagmicrobio.2010.07.014
DO - 10.1016/j.diagmicrobio.2010.07.014
M3 - Article
C2 - 20884158
AN - SCOPUS:78649265630
SN - 0732-8893
VL - 68
SP - 432
EP - 438
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
IS - 4
ER -
