TY - JOUR
T1 - Prevalence and determinants of coronary artery disease in first-degree relatives of premature coronary artery disease
AU - Kang, Min Kyung
AU - Chang, Hyuk Jae
AU - Kim, Young Jin
AU - Park, Ae Ran
AU - Park, Sungha
AU - Jang, Yangsoo
AU - Chung, Namsik
PY - 2012/5
Y1 - 2012/5
N2 - BACKGROUND: This study aimed to investigate the prevalence of subclinical coronary artery disease (CAD) in first-degree relatives (FDRs) with premature CAD and its associating factors other than conventional risk factors. METHODS: A total of 122 FDRs (58 men, 50±7 years) of patients with premature CAD were enrolled. The individuals who had undergone health checkups were included in the control group. Multidetector coronary computed tomography was performed to detect subclinical CAD. RESULTS: The prevalence of subclinical CAD (35 vs. 14%, P<0.001) and at least 50% subclinical CAD (16 vs. 2.5%, P<0.001) was higher in FDRs than that in the control group. In conditional regression analysis, the urinary albumin-creatinine ratio showed a significant interaction with CAD in FDRs than the control (odds ratio 1.063, 95% confidence interval 1.009-1.118, P=0.021). CONCLUSION: FDRs of premature CAD are more prevalent in subclinical CAD independent of conventional risk factors. Urinary albumin-creatinine ratio may have an interaction with the development of subclinical CAD in FDRs of premature CAD.
AB - BACKGROUND: This study aimed to investigate the prevalence of subclinical coronary artery disease (CAD) in first-degree relatives (FDRs) with premature CAD and its associating factors other than conventional risk factors. METHODS: A total of 122 FDRs (58 men, 50±7 years) of patients with premature CAD were enrolled. The individuals who had undergone health checkups were included in the control group. Multidetector coronary computed tomography was performed to detect subclinical CAD. RESULTS: The prevalence of subclinical CAD (35 vs. 14%, P<0.001) and at least 50% subclinical CAD (16 vs. 2.5%, P<0.001) was higher in FDRs than that in the control group. In conditional regression analysis, the urinary albumin-creatinine ratio showed a significant interaction with CAD in FDRs than the control (odds ratio 1.063, 95% confidence interval 1.009-1.118, P=0.021). CONCLUSION: FDRs of premature CAD are more prevalent in subclinical CAD independent of conventional risk factors. Urinary albumin-creatinine ratio may have an interaction with the development of subclinical CAD in FDRs of premature CAD.
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U2 - 10.1097/MCA.0b013e3283515538
DO - 10.1097/MCA.0b013e3283515538
M3 - Article
C2 - 22421547
AN - SCOPUS:84862804554
SN - 0954-6928
VL - 23
SP - 167
EP - 173
JO - Coronary artery disease
JF - Coronary artery disease
IS - 3
ER -