Pretreatment Epstein-Barr virus DNA in whole blood is a prognostic marker in peripheral T-cell lymphoma

Yu Ri Kim, Soo Jeong Kim, June Won Cheong, Haerim Chung, Ji Eun Jang, Yundeok Kim, Woo Ick Yang, Yoo Hong Min, Jin Seok Kim

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10 Citations (Scopus)


Because there are few studies regarding the clinical impact of circulating EBVDNA in peripheral T-cell lymphomas (PTCLs), we tried to evaluate the role of EBVDNA in whole blood as a prognostic factor for PTCL. We retrospectively reviewed 110 PTCL patients with median age of 63 (20-94) years. Forty-seven patients (42.7%) showed positive results for EBV-DNA, and these patients also had stage III/IV disease, elevated lactic dehydrogenase, and low albumin level (P = 0.007, P = 0.004, P = 0.002, respectively). The 5-year overall survival (OS) and progression free survival (PFS) were 21.0% and 18.0%. Univariable analysis showed that positive EBVDNA was related with inferior OS and PFS (P = 0.015 and P < 0.001, respectively). Multivariable analysis showed that poor performance status, extranodal involvement more than one site and positive EBV-DNA results were related with OS and PFS (P < 0.001, P < 0.001, P = 0.007 and P = 0.001, P = 0.002, P < 0.001, respectively). Using these three variables, we made a new prognostic model which classified patients on risk as follows: low, no adverse factors; intermediate, 1 factor; or high, 2-3 factors. The new prognostic model could stratify the three groups for OS and PFS better than either international prognostic index or prognostic index of PTCL-u, and showed statistical significance in PTCL, not otherwise specified. This study suggests that whole blood EBV-DNA is related with aggressive clinical characteristics and inferior survival. The new prognostic model, which incorporates EBV-DNA, could better stratify PTCL patients.

Original languageEnglish
Pages (from-to)92312-92323
Number of pages12
Issue number54
Publication statusPublished - 2017

Bibliographical note

Publisher Copyright:
© Kim et al.

All Science Journal Classification (ASJC) codes

  • Oncology


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