Preparation of poly ε-caprolactone nanoparticles containing magnetite for magnetic drug carrier

J. Yang, S. B. Park, Ho Geun Yoon, Y. M. Huh, S. Haam

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203 Citations (Scopus)


Magnetic poly ε-caprolactone (PCL) nanoparticles were prepared in a well shaped spherical form by the o/w emulsion method. The influence of some preparative variables on the size and surface property was investigated. Nanoparticles were smooth, well individualized and homogeneous in size. The presence of magnetite and its superparamagnetic characteristic were confirmed by transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR) and vibrating sample magnetometer (VSM), respectively. The anti-cancer drug was encapsulated in the magnetic nanoparticle during preparation. A typical release behavior was observed for 30 days. In vitro experiment of magnetic susceptibility under external magnetic field demonstrated that the magnetic PCL nanoparticles have sufficient magnetic susceptibility for a potential magnetic drug carrier for targeted delivery.

Original languageEnglish
Pages (from-to)185-190
Number of pages6
JournalInternational Journal of Pharmaceutics
Issue number2
Publication statusPublished - 2006 Nov 6

Bibliographical note

Funding Information:
This work was supported by KOSEF through National Core Research Center for Nanomedical Technology (R15-2004-024-00000-0) and (R01-2006-000-10023-0), Republic of Korea.

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science


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