Preparation of poly ε-caprolactone nanoparticles containing magnetite for magnetic drug carrier

J. Yang; S. B. Park; Ho Geun Yoon; Y. M. Huh; S. Haam

doi:10.1016/j.ijpharm.2006.06.029

Preparation of poly ε-caprolactone nanoparticles containing magnetite for magnetic drug carrier

J. Yang, S. B. Park, Ho Geun Yoon, Y. M. Huh, S. Haam

Research output: Contribution to journal › Article › peer-review

203 Citations (Scopus)

Abstract

Magnetic poly ε-caprolactone (PCL) nanoparticles were prepared in a well shaped spherical form by the o/w emulsion method. The influence of some preparative variables on the size and surface property was investigated. Nanoparticles were smooth, well individualized and homogeneous in size. The presence of magnetite and its superparamagnetic characteristic were confirmed by transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR) and vibrating sample magnetometer (VSM), respectively. The anti-cancer drug was encapsulated in the magnetic nanoparticle during preparation. A typical release behavior was observed for 30 days. In vitro experiment of magnetic susceptibility under external magnetic field demonstrated that the magnetic PCL nanoparticles have sufficient magnetic susceptibility for a potential magnetic drug carrier for targeted delivery.

Original language	English
Pages (from-to)	185-190
Number of pages	6
Journal	International Journal of Pharmaceutics
Volume	324
Issue number	2
DOIs	https://doi.org/10.1016/j.ijpharm.2006.06.029
Publication status	Published - 2006 Nov 6

Bibliographical note

Funding Information:
This work was supported by KOSEF through National Core Research Center for Nanomedical Technology (R15-2004-024-00000-0) and (R01-2006-000-10023-0), Republic of Korea.

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

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10.1016/j.ijpharm.2006.06.029

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title = "Preparation of poly ε-caprolactone nanoparticles containing magnetite for magnetic drug carrier",

abstract = "Magnetic poly ε-caprolactone (PCL) nanoparticles were prepared in a well shaped spherical form by the o/w emulsion method. The influence of some preparative variables on the size and surface property was investigated. Nanoparticles were smooth, well individualized and homogeneous in size. The presence of magnetite and its superparamagnetic characteristic were confirmed by transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR) and vibrating sample magnetometer (VSM), respectively. The anti-cancer drug was encapsulated in the magnetic nanoparticle during preparation. A typical release behavior was observed for 30 days. In vitro experiment of magnetic susceptibility under external magnetic field demonstrated that the magnetic PCL nanoparticles have sufficient magnetic susceptibility for a potential magnetic drug carrier for targeted delivery.",

author = "J. Yang and Park, {S. B.} and Yoon, {Ho Geun} and Huh, {Y. M.} and S. Haam",

note = "Funding Information: This work was supported by KOSEF through National Core Research Center for Nanomedical Technology (R15-2004-024-00000-0) and (R01-2006-000-10023-0), Republic of Korea.",

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AU - Yang, J.

AU - Park, S. B.

AU - Yoon, Ho Geun

AU - Huh, Y. M.

AU - Haam, S.

N1 - Funding Information: This work was supported by KOSEF through National Core Research Center for Nanomedical Technology (R15-2004-024-00000-0) and (R01-2006-000-10023-0), Republic of Korea.

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N2 - Magnetic poly ε-caprolactone (PCL) nanoparticles were prepared in a well shaped spherical form by the o/w emulsion method. The influence of some preparative variables on the size and surface property was investigated. Nanoparticles were smooth, well individualized and homogeneous in size. The presence of magnetite and its superparamagnetic characteristic were confirmed by transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR) and vibrating sample magnetometer (VSM), respectively. The anti-cancer drug was encapsulated in the magnetic nanoparticle during preparation. A typical release behavior was observed for 30 days. In vitro experiment of magnetic susceptibility under external magnetic field demonstrated that the magnetic PCL nanoparticles have sufficient magnetic susceptibility for a potential magnetic drug carrier for targeted delivery.

AB - Magnetic poly ε-caprolactone (PCL) nanoparticles were prepared in a well shaped spherical form by the o/w emulsion method. The influence of some preparative variables on the size and surface property was investigated. Nanoparticles were smooth, well individualized and homogeneous in size. The presence of magnetite and its superparamagnetic characteristic were confirmed by transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR) and vibrating sample magnetometer (VSM), respectively. The anti-cancer drug was encapsulated in the magnetic nanoparticle during preparation. A typical release behavior was observed for 30 days. In vitro experiment of magnetic susceptibility under external magnetic field demonstrated that the magnetic PCL nanoparticles have sufficient magnetic susceptibility for a potential magnetic drug carrier for targeted delivery.

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Preparation of poly ε-caprolactone nanoparticles containing magnetite for magnetic drug carrier

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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