Nano-sized poly (D,L lactide-co-glycolide) (PLGA) particles, widely used as a biodegradable polymeric carrier, containing estrogen were prepared employing emulsification-diffusion method. Estrogen was chosen as a model drug. The preparation method consists of emulsifying a solution of polymer and drug in the aqueous phase containing stabilizer, previously saturated, followed by adding excess water. Influence of process variables on the mean particle size of nanoparticles has been studied. It was clarified that the type and concentrations of stabilizer, homogenizer speed, polymer concentration determined the size of PLGA nanoparticles. Especially when didodecyl dimethyl ammonium bromide (DMAB) was used as a stabilizer, estrogen containing nanoparticles of smaller than 100 nm was obtained.
|Number of pages
|Colloids and Surfaces A: Physicochemical and Engineering Aspects
|Published - 2001 Jun 30
Bibliographical noteFunding Information:
This work was supported by Korea Research Foundation Grant (KRF-1997-012-E00058) and the Korea Institute of Science and Technology Evaluation and Planning (National Research Laboratory Program, project number 2000-N-NL-01-C-032).
All Science Journal Classification (ASJC) codes
- Surfaces and Interfaces
- Physical and Theoretical Chemistry
- Colloid and Surface Chemistry