Preparation of L-PLA Submicron Particles by a Continuous Supercritical Antisolvent Precipitation Process

Kyu Ho Song, Chang Ha Lee, Jong Sung Lim, Youn Woo Lee

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27 Citations (Scopus)


Submicron particles of L-polylactic acid (L-PLA) without residual solvent were prepared by a continuous supercritical antisolvent (SAS) recrystallization process. Methylene chloride (CH2Cl2) was used as a carrier solvent of L-PLA. Experiments were performed with changing process parameters such as pressure and temperature at constant concentration. Also, L-PLA initial concentrations in methylene chloride were varied from 0.3 to 4 wt%. The flow rates of CO2 and solution, which were introduced into the precipitator, and nozzle diameter were kept unchanged in all of the experiments. It was found that the SAS process gives fine tuning of particle size and particle size distribution (PSD) by simple manipulations of the process parameters. In all cases of SAS recrystallization experiments, the formed spherical fine particles with a smooth surface were non-agglomerated and free flowing. Mean particle size of the L-PLA microparticles formed was varied from 0.1 to 1 μm by means of adjusting the system pressure and/or temperature.

Original languageEnglish
Pages (from-to)139-145
Number of pages7
JournalKorean Journal of Chemical Engineering
Issue number1
Publication statusPublished - 2002 Jan

Bibliographical note

Funding Information:
Tiffs work has been funded by the NationalReseardl Lab (NRL I Program of the Ministry of Science mad Technology and Cleaner Production Progl'alI1 of file Ministly of Colm-nerce, hMustiy and Enelgy.

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)


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