Preparation of gold core-mesoporous iron-oxide shell nanoparticles and their application as dual MR/CT contrast agent in human gastric cancer cells

Aastha Kukreja; Byunghoon Kang; Hyun Ouk Kim; Eunji Jang; Hye Young Son; Yong Min Huh; Seungjoo Haam

doi:10.1016/j.jiec.2016.12.020

Preparation of gold core-mesoporous iron-oxide shell nanoparticles and their application as dual MR/CT contrast agent in human gastric cancer cells

Aastha Kukreja, Byunghoon Kang, Hyun Ouk Kim, Eunji Jang, Hye Young Son, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Multifunctional nano-systems are an enticing approach toward the design of nanoparticles with desired characteristics because of interactions between various components of the system. The combination of various imaging modalities often augments the advantages and simultaneously overcomes restrictions encountered by the individual techniques. This report describes the development of multifunctional gold core/iron oxide porous-shell nanoparticles (AuFe NPs) functionalized with matrix metalloproteinase peptide for targeted multi-mode magnetic resonance and computed tomography imaging. This study demonstrates that AuFe NPs simultaneously possess both T2-based contrast effect and X-ray attenuation properties in vitro. The drug loading capacity of porous iron oxide shell is also proposed.

Original language	English
Pages (from-to)	56-65
Number of pages	10
Journal	Journal of Industrial and Engineering Chemistry
Volume	48
DOIs	https://doi.org/10.1016/j.jiec.2016.12.020
Publication status	Published - 2017

Bibliographical note

Funding Information:
This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MEST) (2012050077 and 2015M3A9D7029834). This research was supported by the Development of Platform Technology for Innovative Medical Measurements Program from Korea research Institute of Standards and Science (KRISS-2016-16011064).

Publisher Copyright:
© 2016 The Korean Society of Industrial and Engineering Chemistry

All Science Journal Classification (ASJC) codes

Chemical Engineering(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jiec.2016.12.020

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title = "Preparation of gold core-mesoporous iron-oxide shell nanoparticles and their application as dual MR/CT contrast agent in human gastric cancer cells",

abstract = "Multifunctional nano-systems are an enticing approach toward the design of nanoparticles with desired characteristics because of interactions between various components of the system. The combination of various imaging modalities often augments the advantages and simultaneously overcomes restrictions encountered by the individual techniques. This report describes the development of multifunctional gold core/iron oxide porous-shell nanoparticles (AuFe NPs) functionalized with matrix metalloproteinase peptide for targeted multi-mode magnetic resonance and computed tomography imaging. This study demonstrates that AuFe NPs simultaneously possess both T2-based contrast effect and X-ray attenuation properties in vitro. The drug loading capacity of porous iron oxide shell is also proposed.",

author = "Aastha Kukreja and Byunghoon Kang and Kim, {Hyun Ouk} and Eunji Jang and Son, {Hye Young} and Huh, {Yong Min} and Seungjoo Haam",

note = "Funding Information: This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MEST) (2012050077 and 2015M3A9D7029834). This research was supported by the Development of Platform Technology for Innovative Medical Measurements Program from Korea research Institute of Standards and Science (KRISS-2016-16011064). Publisher Copyright: {\textcopyright} 2016 The Korean Society of Industrial and Engineering Chemistry",

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doi = "10.1016/j.jiec.2016.12.020",

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AU - Kukreja, Aastha

AU - Kang, Byunghoon

AU - Kim, Hyun Ouk

AU - Jang, Eunji

AU - Son, Hye Young

AU - Huh, Yong Min

AU - Haam, Seungjoo

N1 - Funding Information: This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MEST) (2012050077 and 2015M3A9D7029834). This research was supported by the Development of Platform Technology for Innovative Medical Measurements Program from Korea research Institute of Standards and Science (KRISS-2016-16011064). Publisher Copyright: © 2016 The Korean Society of Industrial and Engineering Chemistry

PY - 2017

Y1 - 2017

N2 - Multifunctional nano-systems are an enticing approach toward the design of nanoparticles with desired characteristics because of interactions between various components of the system. The combination of various imaging modalities often augments the advantages and simultaneously overcomes restrictions encountered by the individual techniques. This report describes the development of multifunctional gold core/iron oxide porous-shell nanoparticles (AuFe NPs) functionalized with matrix metalloproteinase peptide for targeted multi-mode magnetic resonance and computed tomography imaging. This study demonstrates that AuFe NPs simultaneously possess both T2-based contrast effect and X-ray attenuation properties in vitro. The drug loading capacity of porous iron oxide shell is also proposed.

AB - Multifunctional nano-systems are an enticing approach toward the design of nanoparticles with desired characteristics because of interactions between various components of the system. The combination of various imaging modalities often augments the advantages and simultaneously overcomes restrictions encountered by the individual techniques. This report describes the development of multifunctional gold core/iron oxide porous-shell nanoparticles (AuFe NPs) functionalized with matrix metalloproteinase peptide for targeted multi-mode magnetic resonance and computed tomography imaging. This study demonstrates that AuFe NPs simultaneously possess both T2-based contrast effect and X-ray attenuation properties in vitro. The drug loading capacity of porous iron oxide shell is also proposed.

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EP - 65

JO - Journal of Industrial and Engineering Chemistry

JF - Journal of Industrial and Engineering Chemistry

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Preparation of gold core-mesoporous iron-oxide shell nanoparticles and their application as dual MR/CT contrast agent in human gastric cancer cells

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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