Preparation of chitosan microspheres using membrane emulsification and its size modelling

S. B. Park; Y. J. Jeon; S. Haam; H. Y. Park; W. S. Kim

doi:10.1080/02652040410001729304

Preparation of chitosan microspheres using membrane emulsification and its size modelling

S. B. Park, Y. J. Jeon, S. Haam, H. Y. Park, W. S. Kim

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The chitosan microspheres were prepared by a membrane emulsification method with variations of the N₂ gas pressure and the chitosan concentration. The pressure of N₂ gas was varied within the range from 0.2 × 10⁵ to 0.8 × 10⁵ Pa at chitosan concentration 1.5 wt%. In addition, the concentration of chitosan was varied between 0.5-2.0 wt% at 0.4 × 10⁵ Pa of N₂ gas pressure. Using this method, it is possible to prepare stable emulsions with a very narrow droplet size distribution in comparison with conventional methods. The average size of the microspheres was dependent on the N₂ gas pressure and the concentration, that is it was increased with the pressure and the concentration. The modelling of the size for the microspheres according to the concentration was carried out using Macleod's relation and Parkins & Brown equation. The former shows the relationship between density and surface tension and the latter demonstrates the correlation between the volume of the microspheres and the interfacial tension. The modelling results were in good agreement with the experimental data to predict the microspheres size with the variation of concentration.

Original language	English
Pages (from-to)	539-552
Number of pages	14
Journal	Journal of Microencapsulation
Volume	21
Issue number	5
DOIs	https://doi.org/10.1080/02652040410001729304
Publication status	Published - 2004 Aug

Bibliographical note

Funding Information:
This research, under the contract project code MS-00-112-01, has been supported by the Intelligent Microsystem Centre (IMC: http://www.microsys-tem.re.kr), which carries out one of the 21st century’s Frontier R & D projects sponsored by the Korea Ministry of Science & Technology.

All Science Journal Classification (ASJC) codes

Bioengineering
Pharmaceutical Science
Physical and Theoretical Chemistry
Organic Chemistry
Colloid and Surface Chemistry

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10.1080/02652040410001729304

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abstract = "The chitosan microspheres were prepared by a membrane emulsification method with variations of the N2 gas pressure and the chitosan concentration. The pressure of N2 gas was varied within the range from 0.2 × 105 to 0.8 × 105 Pa at chitosan concentration 1.5 wt%. In addition, the concentration of chitosan was varied between 0.5-2.0 wt% at 0.4 × 105 Pa of N2 gas pressure. Using this method, it is possible to prepare stable emulsions with a very narrow droplet size distribution in comparison with conventional methods. The average size of the microspheres was dependent on the N2 gas pressure and the concentration, that is it was increased with the pressure and the concentration. The modelling of the size for the microspheres according to the concentration was carried out using Macleod's relation and Parkins & Brown equation. The former shows the relationship between density and surface tension and the latter demonstrates the correlation between the volume of the microspheres and the interfacial tension. The modelling results were in good agreement with the experimental data to predict the microspheres size with the variation of concentration.",

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AU - Jeon, Y. J.

AU - Haam, S.

AU - Park, H. Y.

AU - Kim, W. S.

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PY - 2004/8

Y1 - 2004/8

N2 - The chitosan microspheres were prepared by a membrane emulsification method with variations of the N2 gas pressure and the chitosan concentration. The pressure of N2 gas was varied within the range from 0.2 × 105 to 0.8 × 105 Pa at chitosan concentration 1.5 wt%. In addition, the concentration of chitosan was varied between 0.5-2.0 wt% at 0.4 × 105 Pa of N2 gas pressure. Using this method, it is possible to prepare stable emulsions with a very narrow droplet size distribution in comparison with conventional methods. The average size of the microspheres was dependent on the N2 gas pressure and the concentration, that is it was increased with the pressure and the concentration. The modelling of the size for the microspheres according to the concentration was carried out using Macleod's relation and Parkins & Brown equation. The former shows the relationship between density and surface tension and the latter demonstrates the correlation between the volume of the microspheres and the interfacial tension. The modelling results were in good agreement with the experimental data to predict the microspheres size with the variation of concentration.

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Preparation of chitosan microspheres using membrane emulsification and its size modelling

Abstract

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