Preparation of chitosan microspheres using membrane emulsification and its size modelling

S. B. Park, Y. J. Jeon, S. Haam, H. Y. Park, W. S. Kim

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The chitosan microspheres were prepared by a membrane emulsification method with variations of the N2 gas pressure and the chitosan concentration. The pressure of N2 gas was varied within the range from 0.2 × 105 to 0.8 × 105 Pa at chitosan concentration 1.5 wt%. In addition, the concentration of chitosan was varied between 0.5-2.0 wt% at 0.4 × 105 Pa of N2 gas pressure. Using this method, it is possible to prepare stable emulsions with a very narrow droplet size distribution in comparison with conventional methods. The average size of the microspheres was dependent on the N2 gas pressure and the concentration, that is it was increased with the pressure and the concentration. The modelling of the size for the microspheres according to the concentration was carried out using Macleod's relation and Parkins & Brown equation. The former shows the relationship between density and surface tension and the latter demonstrates the correlation between the volume of the microspheres and the interfacial tension. The modelling results were in good agreement with the experimental data to predict the microspheres size with the variation of concentration.

Original languageEnglish
Pages (from-to)539-552
Number of pages14
JournalJournal of Microencapsulation
Issue number5
Publication statusPublished - 2004 Aug

Bibliographical note

Funding Information:
This research, under the contract project code MS-00-112-01, has been supported by the Intelligent Microsystem Centre (IMC:, which carries out one of the 21st century’s Frontier R & D projects sponsored by the Korea Ministry of Science & Technology.

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Pharmaceutical Science
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Colloid and Surface Chemistry


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