Prediagnosis Leisure-Time Physical Activity and Lung Cancer Survival: A Pooled Analysis of 11 Cohorts

Jae Jeong Yang, Danxia Yu, Emily White, Dong Hoon Lee, William Blot, Kim Robien, Rashmi Sinha, Yikyung Park, Yumie Takata, Yu Tang Gao, Karl Smith-Byrne, Evelyn M. Monninkhof, Rudolf Kaaks, Arnulf Langhammer, Kristin Benjaminsen Borch, Laila Al-Shaar, Qing Lan, Elin Pettersen Sørgjerd, Xuehong Zhang, Clair ZhuMaría Dolores Chirlaque, Gianluca Severi, Kim Overvad, Carlotta Sacerdote, Dagfinn Aune, Mattias Johansson, Stephanie A. Smith-Warner, Wei Zheng, Xiao Ou Shu

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Background: Little is known about the association between physical activity before cancer diagnosis and survival among lung cancer patients. In this pooled analysis of 11 prospective cohorts, we investigated associations of prediagnosis leisure-time physical activity (LTPA) with all-cause and lung cancer-specific mortality among incident lung cancer patients. Methods: Using self-reported data on regular engagement in exercise and sports activities collected at study enrollment, we assessed metabolic equivalent hours (MET-h) of prediagnosis LTPA per week. According to the Physical Activity Guidelines for Americans, prediagnosis LTPA was classified into inactivity, less than 8.3 and at least 8.3 MET-h per week (the minimum recommended range). Cox regression was used to estimate hazard ratios (HRs) and 95% confidence interval (CIs) for all-cause and lung cancer-specific mortality after adjustment for major prognostic factors and lifetime smoking history. Results: Of 20 494 incident lung cancer patients, 16 864 died, including 13 596 deaths from lung cancer (overall 5-year relative survival rate = 20.9%, 95% CI = 20.3% to 21.5%). Compared with inactivity, prediagnosis LTPA of more than 8.3 MET-h per week was associated with a lower hazard of all-cause mortality (multivariable-adjusted HR = 0.93, 95% CI = 0.88 to 0.99), but not with lung cancer-specific mortality (multivariable-adjusted HR = 0.99, 95% CI = 0.95 to 1.04), among the overall population. Additive interaction was found by tumor stage (Pinteraction =. 008 for all-cause mortality and. 003 for lung cancer-specific mortality). When restricted to localized cancer, prediagnosis LTPA of at least 8.3 MET-h per week linked to 20% lower mortality: multivariable-adjusted HRs were 0.80 (95% CI = 0.67 to 0.97) for all-cause mortality and 0.80 (95% CI = 0.65 to 0.99) for lung cancer-specific mortality. Conclusions: Regular participation in LTPA that met or exceeded the minimum Physical Activity Guidelines was associated with reduced hazards of mortality among lung cancer patients, especially those with early stage cancer.

Original languageEnglish
Article numberpkac009
JournalJNCI Cancer Spectrum
Volume6
Issue number2
DOIs
Publication statusPublished - 2022 Apr 1

Bibliographical note

Publisher Copyright:
© 2022 The Author(s). Published by Oxford University Press.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Prediagnosis Leisure-Time Physical Activity and Lung Cancer Survival: A Pooled Analysis of 11 Cohorts'. Together they form a unique fingerprint.

Cite this