Postoperative Effects of Thiopurines in Patients with Intestinal Behçet’s Disease

Hye Won Lee, Jae Hee Cheon, Hyun Jung Lee, Soo Jung Park, Sung Pil Hong, Tae Il Kim, Won Ho Kim

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10 Citations (Scopus)


Background: No studies have heretofore specifically focused on the efficacy of postoperative thiopurine therapy in intestinal Behçet’s disease (BD). We conducted this study to assess the clinical effects of postoperative thiopurines in patients with intestinal BD. Methods: We reviewed the medical records of all patients with intestinal BD who had undergone bowel resection surgery in a single tertiary academic medical center between 1991 and 2013. The cumulative probabilities of clinical recurrence were calculated using the Kaplan–Meier method, and predictive factors for recurrence were assessed by multivariate analysis. Results: A total of 77 patients with intestinal BD received 5-ASA (n = 50, 64.9 %) or thiopurine (n = 27, 35.1 %) therapy after surgery at our center. The postoperative recurrence rate was lower in patients who received postoperative thiopurines (P = 0.050). The hazard ratio for recurrence was 0.636 (95 % confidence interval 0.130–1.016, P = 0.053) for postoperative thiopurine use compared with postoperative 5-ASA. However, the rates of re-operation, re-admission, and death were not significantly different between the 5-ASA and thiopurine groups. Conclusions: Thiopurine therapy after surgery exhibited a modest effect in preventing recurrence in intestinal BD patients. More patients, long-term follow-up, and a randomized controlled design are necessary to validate the effectiveness of postoperative thiopurines in patients with this disease.

Original languageEnglish
Pages (from-to)3721-3727
Number of pages7
JournalDigestive diseases and sciences
Issue number12
Publication statusPublished - 2015 Dec 1

Bibliographical note

Funding Information:
This research was supported by the grants of the Korean Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (Grant Numbers A111428, A120176, and HI13C1345), and it was supported by a faculty research grant of Yonsei University College of Medicine for 2012 (6-2012-0135).

Publisher Copyright:
© 2015, Springer Science+Business Media New York.

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology


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