Portal hypertensive gastropathy: Correlation with portal hypertension and prognosis in cirrhosis

Moon Young Kim, Hoon Choi, Soon Koo Baik, Chang Jin Yea, Chan Sik Won, Jong Won Byun, So Yeon Park, Yong Hwan Kwon, Jae Woo Kim, Hyun Soo Kim, Sang Ok Kwon, Young Ju Kim, Seung Hwan Cha, Sei Jin Chang

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41 Citations (Scopus)


Background: Portal hypertensive gastropathy (PHG) is a common endoscopic finding in patients with cirrhosis. However, the relationship between PHG and portal hypertension is controversial. Furthermore, nothing is known regarding the correlation between PHG and prognosis in patients with cirrhosis. Methods: The hepatic venous pressure gradient (HVPG), endoscopic PHG grade, Child-Pugh score, and model for end-stage liver disease (MELD) score were assessed at baseline and were followed prospectively in 331 cirrhotic patients (284 males, 85.8%; mean age, 52.16 ± 9.05 years) from January 2001 to April 2009. The relationship between PHG with HVPG and survival was investigated. Results: The HVPG was significantly higher in patients with severe PHG than in those with mild or no PHG (absent, 4.9 ± 1.7 mmHg; mild, 10.7 ± 4.1 mmHg; severe, 15.6 ± 4.6 mmHg; P < 0.001). During follow-up, 28 patients (8.5%) died from liver-related disease. In the Cox regression analysis, severe PHG (none and mild vs. severe) (hazard ratio 1.153, 95% confidence interval: 1.048-1.269) showed a significantly high relative risk of mortality, and in the Kaplan-Meier analysis, severe PHG showed a significantly shorter expected survival time than none or mild PHG (median survival time, 77.6 ± 9.6 months in severe PHG; log-rank test, P = 0.030). Conclusions: PHG was associated with portal hypertension severity and prognosis in patients with cirrhosis.

Original languageEnglish
Pages (from-to)3561-3567
Number of pages7
JournalDigestive diseases and sciences
Issue number12
Publication statusPublished - 2010 Dec

Bibliographical note

Funding Information:
Acknowledgments This work was supported by a grant (no. A050021) from the Ministry for Health, Welfare, and Family Affairs, Republic of Korea.

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology


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