TY - JOUR
T1 - Portal hypertensive gastropathy
T2 - Correlation with portal hypertension and prognosis in cirrhosis
AU - Kim, Moon Young
AU - Choi, Hoon
AU - Baik, Soon Koo
AU - Yea, Chang Jin
AU - Won, Chan Sik
AU - Byun, Jong Won
AU - Park, So Yeon
AU - Kwon, Yong Hwan
AU - Kim, Jae Woo
AU - Kim, Hyun Soo
AU - Kwon, Sang Ok
AU - Kim, Young Ju
AU - Cha, Seung Hwan
AU - Chang, Sei Jin
N1 - Funding Information:
Acknowledgments This work was supported by a grant (no. A050021) from the Ministry for Health, Welfare, and Family Affairs, Republic of Korea.
PY - 2010/12
Y1 - 2010/12
N2 - Background: Portal hypertensive gastropathy (PHG) is a common endoscopic finding in patients with cirrhosis. However, the relationship between PHG and portal hypertension is controversial. Furthermore, nothing is known regarding the correlation between PHG and prognosis in patients with cirrhosis. Methods: The hepatic venous pressure gradient (HVPG), endoscopic PHG grade, Child-Pugh score, and model for end-stage liver disease (MELD) score were assessed at baseline and were followed prospectively in 331 cirrhotic patients (284 males, 85.8%; mean age, 52.16 ± 9.05 years) from January 2001 to April 2009. The relationship between PHG with HVPG and survival was investigated. Results: The HVPG was significantly higher in patients with severe PHG than in those with mild or no PHG (absent, 4.9 ± 1.7 mmHg; mild, 10.7 ± 4.1 mmHg; severe, 15.6 ± 4.6 mmHg; P < 0.001). During follow-up, 28 patients (8.5%) died from liver-related disease. In the Cox regression analysis, severe PHG (none and mild vs. severe) (hazard ratio 1.153, 95% confidence interval: 1.048-1.269) showed a significantly high relative risk of mortality, and in the Kaplan-Meier analysis, severe PHG showed a significantly shorter expected survival time than none or mild PHG (median survival time, 77.6 ± 9.6 months in severe PHG; log-rank test, P = 0.030). Conclusions: PHG was associated with portal hypertension severity and prognosis in patients with cirrhosis.
AB - Background: Portal hypertensive gastropathy (PHG) is a common endoscopic finding in patients with cirrhosis. However, the relationship between PHG and portal hypertension is controversial. Furthermore, nothing is known regarding the correlation between PHG and prognosis in patients with cirrhosis. Methods: The hepatic venous pressure gradient (HVPG), endoscopic PHG grade, Child-Pugh score, and model for end-stage liver disease (MELD) score were assessed at baseline and were followed prospectively in 331 cirrhotic patients (284 males, 85.8%; mean age, 52.16 ± 9.05 years) from January 2001 to April 2009. The relationship between PHG with HVPG and survival was investigated. Results: The HVPG was significantly higher in patients with severe PHG than in those with mild or no PHG (absent, 4.9 ± 1.7 mmHg; mild, 10.7 ± 4.1 mmHg; severe, 15.6 ± 4.6 mmHg; P < 0.001). During follow-up, 28 patients (8.5%) died from liver-related disease. In the Cox regression analysis, severe PHG (none and mild vs. severe) (hazard ratio 1.153, 95% confidence interval: 1.048-1.269) showed a significantly high relative risk of mortality, and in the Kaplan-Meier analysis, severe PHG showed a significantly shorter expected survival time than none or mild PHG (median survival time, 77.6 ± 9.6 months in severe PHG; log-rank test, P = 0.030). Conclusions: PHG was associated with portal hypertension severity and prognosis in patients with cirrhosis.
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U2 - 10.1007/s10620-010-1221-6
DO - 10.1007/s10620-010-1221-6
M3 - Article
C2 - 20407828
AN - SCOPUS:78649311188
SN - 0163-2116
VL - 55
SP - 3561
EP - 3567
JO - Digestive diseases and sciences
JF - Digestive diseases and sciences
IS - 12
ER -