Porphyrins as spectroscopic sensors for conformational studies of DNA

Milan Balaz; Klaus Bitsch-Jensen; Angela Mammana; George A. Ellestad; Koji Nakanishi; Nina Berova

doi:10.1351/pac200779040801

Porphyrins as spectroscopic sensors for conformational studies of DNA

Milan Balaz, Klaus Bitsch-Jensen, Angela Mammana, George A. Ellestad, Koji Nakanishi, Nina Berova

Integrated Sciences and Engineering Division

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Molecular systems containing two or more interacting porphyrins show remarkable spectroscopic features that allow for a very sensitive detection of conformational changes on the microscale level by different methods, such as fluorescence and electronic circular dichroism (ECD). Covalent porphyrin-DNA assemblies can provide a CD profile (exciton couplet) within the porphyrin Soret band region which is very diagnostic for DNA conformational changes. Additionally, covalently linked porphyrins have been shown to function as DNA molecular caps and to stabilize the non-self-complementary non-Watson-Crick guanine-adenine DNA sequence via their strong π-π stacking.

Original language	English
Pages (from-to)	801-809
Number of pages	9
Journal	Pure and Applied Chemistry
Volume	79
Issue number	4
DOIs	https://doi.org/10.1351/pac200779040801
Publication status	Published - 2007 Apr

Bibliographical note

Funding Information:
This work is supported in part by NIH and NSF, USA.

All Science Journal Classification (ASJC) codes

Chemistry(all)
Chemical Engineering(all)

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title = "Porphyrins as spectroscopic sensors for conformational studies of DNA",

abstract = "Molecular systems containing two or more interacting porphyrins show remarkable spectroscopic features that allow for a very sensitive detection of conformational changes on the microscale level by different methods, such as fluorescence and electronic circular dichroism (ECD). Covalent porphyrin-DNA assemblies can provide a CD profile (exciton couplet) within the porphyrin Soret band region which is very diagnostic for DNA conformational changes. Additionally, covalently linked porphyrins have been shown to function as DNA molecular caps and to stabilize the non-self-complementary non-Watson-Crick guanine-adenine DNA sequence via their strong π-π stacking.",

author = "Milan Balaz and Klaus Bitsch-Jensen and Angela Mammana and Ellestad, {George A.} and Koji Nakanishi and Nina Berova",

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AU - Balaz, Milan

AU - Bitsch-Jensen, Klaus

AU - Mammana, Angela

AU - Ellestad, George A.

AU - Nakanishi, Koji

AU - Berova, Nina

N1 - Funding Information: This work is supported in part by NIH and NSF, USA.

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AB - Molecular systems containing two or more interacting porphyrins show remarkable spectroscopic features that allow for a very sensitive detection of conformational changes on the microscale level by different methods, such as fluorescence and electronic circular dichroism (ECD). Covalent porphyrin-DNA assemblies can provide a CD profile (exciton couplet) within the porphyrin Soret band region which is very diagnostic for DNA conformational changes. Additionally, covalently linked porphyrins have been shown to function as DNA molecular caps and to stabilize the non-self-complementary non-Watson-Crick guanine-adenine DNA sequence via their strong π-π stacking.

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Porphyrins as spectroscopic sensors for conformational studies of DNA

Abstract

Bibliographical note

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