Porous hyaluronic acid/sodium alginate composite scaffolds for human adipose-derived stem cells delivery

Yun Jeong Son; In Soo Yoon; Jong Hyuk Sung; Hyun Jong Cho; Suk Jae Chung; Chang Koo Shim; Dae Duk Kim

doi:10.1016/j.ijbiomac.2013.06.023

Porous hyaluronic acid/sodium alginate composite scaffolds for human adipose-derived stem cells delivery

Yun Jeong Son, In Soo Yoon, Jong Hyuk Sung, Hyun Jong Cho, Suk Jae Chung, Chang Koo Shim, Dae Duk Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

The aim of this study is to evaluate the feasibility of hyaluronic acid/sodium alginate (HA/SA) scaffold-based interpenetrating polymeric network (IPN) for the proliferation and chondrogenic differentiation of the human adipose-derived stem cells (hADSCs). The hADSCs cultured in HA/SA IPN scaffold exhibited enhanced cell adhesion and proliferation compared to the HA scaffold. Superior chondrogenic differentiation of hADSCs in HA/SA IPN scaffold, compared to HA-based scaffold, was confirmed by measuring expression levels of chondrogenic markers. These results suggested that HA/SA IPN scaffold could provide a desirable environment for the cell adhesion, proliferation and chondrogenic differentiation of hADSCs.

Original language	English
Pages (from-to)	175-181
Number of pages	7
Journal	International Journal of Biological Macromolecules
Volume	61
DOIs	https://doi.org/10.1016/j.ijbiomac.2013.06.023
Publication status	Published - 2013 Oct

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. 2009-0083533 ).

All Science Journal Classification (ASJC) codes

Structural Biology
Biochemistry
Molecular Biology
Economics and Econometrics
Energy(all)

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10.1016/j.ijbiomac.2013.06.023

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title = "Porous hyaluronic acid/sodium alginate composite scaffolds for human adipose-derived stem cells delivery",

abstract = "The aim of this study is to evaluate the feasibility of hyaluronic acid/sodium alginate (HA/SA) scaffold-based interpenetrating polymeric network (IPN) for the proliferation and chondrogenic differentiation of the human adipose-derived stem cells (hADSCs). The hADSCs cultured in HA/SA IPN scaffold exhibited enhanced cell adhesion and proliferation compared to the HA scaffold. Superior chondrogenic differentiation of hADSCs in HA/SA IPN scaffold, compared to HA-based scaffold, was confirmed by measuring expression levels of chondrogenic markers. These results suggested that HA/SA IPN scaffold could provide a desirable environment for the cell adhesion, proliferation and chondrogenic differentiation of hADSCs.",

author = "Son, {Yun Jeong} and Yoon, {In Soo} and Sung, {Jong Hyuk} and Cho, {Hyun Jong} and Chung, {Suk Jae} and Shim, {Chang Koo} and Kim, {Dae Duk}",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. 2009-0083533 ). ",

year = "2013",

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doi = "10.1016/j.ijbiomac.2013.06.023",

language = "English",

volume = "61",

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journal = "International Journal of Biological Macromolecules",

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AU - Son, Yun Jeong

AU - Yoon, In Soo

AU - Sung, Jong Hyuk

AU - Cho, Hyun Jong

AU - Chung, Suk Jae

AU - Shim, Chang Koo

AU - Kim, Dae Duk

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. 2009-0083533 ).

PY - 2013/10

Y1 - 2013/10

N2 - The aim of this study is to evaluate the feasibility of hyaluronic acid/sodium alginate (HA/SA) scaffold-based interpenetrating polymeric network (IPN) for the proliferation and chondrogenic differentiation of the human adipose-derived stem cells (hADSCs). The hADSCs cultured in HA/SA IPN scaffold exhibited enhanced cell adhesion and proliferation compared to the HA scaffold. Superior chondrogenic differentiation of hADSCs in HA/SA IPN scaffold, compared to HA-based scaffold, was confirmed by measuring expression levels of chondrogenic markers. These results suggested that HA/SA IPN scaffold could provide a desirable environment for the cell adhesion, proliferation and chondrogenic differentiation of hADSCs.

AB - The aim of this study is to evaluate the feasibility of hyaluronic acid/sodium alginate (HA/SA) scaffold-based interpenetrating polymeric network (IPN) for the proliferation and chondrogenic differentiation of the human adipose-derived stem cells (hADSCs). The hADSCs cultured in HA/SA IPN scaffold exhibited enhanced cell adhesion and proliferation compared to the HA scaffold. Superior chondrogenic differentiation of hADSCs in HA/SA IPN scaffold, compared to HA-based scaffold, was confirmed by measuring expression levels of chondrogenic markers. These results suggested that HA/SA IPN scaffold could provide a desirable environment for the cell adhesion, proliferation and chondrogenic differentiation of hADSCs.

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Porous hyaluronic acid/sodium alginate composite scaffolds for human adipose-derived stem cells delivery

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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