Polymeric supramolecular assemblies based on multivalent ionic interactions for biomedical applications

Hongsik Yoon, Emma J. Dell, Jessica L. Freyer, Luis M. Campos, Woo Dong Jang

Research output: Contribution to journalReview articlepeer-review

47 Citations (Scopus)


Oppositely charged polyelectrolytes can be used to form various types of self-assembled structures directed by multivalent ionic interactions. The supramolecular architectures that result are often referred to as polyion complexes (PICs). Synthetic polyion complexes are exciting candidates for biomedical applications. Their self-assembly capabilities give rise to hierarchical mesoscopic platforms such as micelles, membranes, and capsules through simple mixing processes. These complexes are also ideal candidates for the transport and delivery of biological agents since biomolecules, such as DNA and proteins can be easily incorporated through ionic interactions. PICs have therefore found use in drug delivery, diagnostics, gene therapy, biosensors and microreactors. In this paper, we briefly review examples of polymeric supramolecular assemblies based on multivalent ionic interactions for biomedical applications.

Original languageEnglish
Pages (from-to)453-464
Number of pages12
Issue number2
Publication statusPublished - 2014 Jan 30

Bibliographical note

Funding Information:
The authors acknowledge financial support by Mid-Career Researcher Program through NRF grant funded by the MEST (No. 2012005565 ).

Funding Information:
Luis M. Campos is an Assistant Professor in the Department of Chemistry at Columbia University (joined in 2011). His group's research interests lie in polymer chemistry and directed self-assembly, with an emphasis on understanding semiconducting polymers and biomaterials at the molecular level. Luis was born in Guadalajara, Mexico, and moved at an early age to Los Angeles, where he began his Californian public education in middle school. He received a B.Sc. in Chemistry from CSU Dominguez Hills in 2001, and a Ph.D. from the Department of Chemistry & Biochemistry at UCLA in 2006 working under the supervision of M. A. Garcia-Garibay and K. N. Houk. At UCLA, he was awarded the NSF Predoctoral Fellowship, Paul & Daisy Soros Fellowship, and the Saul & Silvia Winstein Award for his graduate research in solid-state photochemistry. Switching to materials chemistry, he went to UCSB as a UC President's Postdoctoral Fellow to work under the supervision of C. J. Hawker at the Materials Research Laboratory, exploring thiol-ene click chemistry in polymer-based applications.

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry


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