Polyamine patterns in the cerebrospinal fluid of patients with Parkinson's disease and multiple system atrophy

Man Jeong Paik; Young Hwan Ahn; Phil Hyu Lee; Hyunseung Kang; Chan Bae Park; Sangdun Choi; Gwang Lee

doi:10.1016/j.cca.2010.05.034

Polyamine patterns in the cerebrospinal fluid of patients with Parkinson's disease and multiple system atrophy

Man Jeong Paik, Young Hwan Ahn, Phil Hyu Lee, Hyunseung Kang, Chan Bae Park, Sangdun Choi, Gwang Lee

Department of Neurology

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

Background: Polyamines (PAs) are important modulators of physiological condition, and are associated with neurodegenerative disease. Thus, we investigated the change of PA concentration in the cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) and multiple system atrophy (MSA). Methods: CSF samples from patients with PD and MSA were examined by gas chromatography-mass spectrometry in selected ion monitoring mode using N-ethoxycarbonyl/. N-pentafluoropropyonyl derivatives. Results: PA concentrations were significantly different in patients with PD and MSA compared with those in the normal group. In the PD group, as compared with the MSA group, concentrations of putrescine, N¹-acetylspermidine, and putrescine spermidine^-1 were significantly increased, whereas the concentration of spermidine was significantly reduced. Conclusions: These results could be helpful for understanding the complexity of biochemical events in patients with PD and MSA, and may serve as metabolic markers for diagnosis of PD and MSA.

Original language	English
Pages (from-to)	1532-1535
Number of pages	4
Journal	Clinica Chimica Acta
Volume	411
Issue number	19-20
DOIs	https://doi.org/10.1016/j.cca.2010.05.034
Publication status	Published - 2010 Oct

Bibliographical note

Funding Information:
T his work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD, Basic Research Promotion Fund) (KRF-2007-313-H00012) to G.L., Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2009-0093826), and the Korea Research Foundation (KRF) grant funded by the Korea government (MEST) (No. 2010-0016256) to S.C.

All Science Journal Classification (ASJC) codes

Biochemistry
Clinical Biochemistry
Biochemistry, medical

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10.1016/j.cca.2010.05.034

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title = "Polyamine patterns in the cerebrospinal fluid of patients with Parkinson's disease and multiple system atrophy",

abstract = "Background: Polyamines (PAs) are important modulators of physiological condition, and are associated with neurodegenerative disease. Thus, we investigated the change of PA concentration in the cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) and multiple system atrophy (MSA). Methods: CSF samples from patients with PD and MSA were examined by gas chromatography-mass spectrometry in selected ion monitoring mode using N-ethoxycarbonyl/. N-pentafluoropropyonyl derivatives. Results: PA concentrations were significantly different in patients with PD and MSA compared with those in the normal group. In the PD group, as compared with the MSA group, concentrations of putrescine, N1-acetylspermidine, and putrescine spermidine-1 were significantly increased, whereas the concentration of spermidine was significantly reduced. Conclusions: These results could be helpful for understanding the complexity of biochemical events in patients with PD and MSA, and may serve as metabolic markers for diagnosis of PD and MSA.",

author = "Paik, {Man Jeong} and Ahn, {Young Hwan} and Lee, {Phil Hyu} and Hyunseung Kang and Park, {Chan Bae} and Sangdun Choi and Gwang Lee",

note = "Funding Information: T his work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD, Basic Research Promotion Fund) (KRF-2007-313-H00012) to G.L., Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2009-0093826), and the Korea Research Foundation (KRF) grant funded by the Korea government (MEST) (No. 2010-0016256) to S.C.",

year = "2010",

month = oct,

doi = "10.1016/j.cca.2010.05.034",

language = "English",

volume = "411",

pages = "1532--1535",

journal = "Clinica Chimica Acta",

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T1 - Polyamine patterns in the cerebrospinal fluid of patients with Parkinson's disease and multiple system atrophy

AU - Paik, Man Jeong

AU - Ahn, Young Hwan

AU - Lee, Phil Hyu

AU - Kang, Hyunseung

AU - Park, Chan Bae

AU - Choi, Sangdun

AU - Lee, Gwang

N1 - Funding Information: T his work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD, Basic Research Promotion Fund) (KRF-2007-313-H00012) to G.L., Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2009-0093826), and the Korea Research Foundation (KRF) grant funded by the Korea government (MEST) (No. 2010-0016256) to S.C.

PY - 2010/10

Y1 - 2010/10

N2 - Background: Polyamines (PAs) are important modulators of physiological condition, and are associated with neurodegenerative disease. Thus, we investigated the change of PA concentration in the cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) and multiple system atrophy (MSA). Methods: CSF samples from patients with PD and MSA were examined by gas chromatography-mass spectrometry in selected ion monitoring mode using N-ethoxycarbonyl/. N-pentafluoropropyonyl derivatives. Results: PA concentrations were significantly different in patients with PD and MSA compared with those in the normal group. In the PD group, as compared with the MSA group, concentrations of putrescine, N1-acetylspermidine, and putrescine spermidine-1 were significantly increased, whereas the concentration of spermidine was significantly reduced. Conclusions: These results could be helpful for understanding the complexity of biochemical events in patients with PD and MSA, and may serve as metabolic markers for diagnosis of PD and MSA.

AB - Background: Polyamines (PAs) are important modulators of physiological condition, and are associated with neurodegenerative disease. Thus, we investigated the change of PA concentration in the cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) and multiple system atrophy (MSA). Methods: CSF samples from patients with PD and MSA were examined by gas chromatography-mass spectrometry in selected ion monitoring mode using N-ethoxycarbonyl/. N-pentafluoropropyonyl derivatives. Results: PA concentrations were significantly different in patients with PD and MSA compared with those in the normal group. In the PD group, as compared with the MSA group, concentrations of putrescine, N1-acetylspermidine, and putrescine spermidine-1 were significantly increased, whereas the concentration of spermidine was significantly reduced. Conclusions: These results could be helpful for understanding the complexity of biochemical events in patients with PD and MSA, and may serve as metabolic markers for diagnosis of PD and MSA.

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Polyamine patterns in the cerebrospinal fluid of patients with Parkinson's disease and multiple system atrophy

Abstract

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