Plug-and-play safe-by-design production of metal-doped tellurium nanoparticles with safer antimicrobial activities

Dae Hoon Park, Milan Gautam, Sung Jae Park, Jungho Hwang, Chul Soon Yong, Jong Oh Kim, Jeong Hoon Byeon

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Safe-by-design principles, such as optimum balance of material function and safety, have received much recent attention. On-demand production is also receiving great interest in the realization of nanotechnologies that meet unpredictable demands of reconfiguration and modification to maximize the efficacy of materials processing. Antimicrobial nanomaterials are representative subjects of these approaches, because they require built-to-order configurations with safe-by-design principles for practical applications. However, few studies have achieved biosafety with original material function using economically feasible production platforms. In this regard, we developed a safe-by-design plug-and-play approach for continuous gas flow production of silver (or copper)-doped tellurium (Ag- or Cu-Te) nanoparticles with safer antimicrobial activity. Using this approach, we achieved precise modulation of dopant contents (5-8% atomic Ag and Cu) in nanoparticles without using batch hydrothermal chemistry. We also suggest the use of ratios between biocompatibility and antimicrobial activity as safety indices (SIs) for evaluations of nanoparticle applications. Approximately 6% atomic Ag in Ag-Te particles exhibited an optimal SI and significantly reduced the minimum inhibitory concentration of individual Te nanoparticles.

Original languageEnglish
Pages (from-to)2074-2083
Number of pages10
JournalEnvironmental Science: Nano
Issue number7
Publication statusPublished - 2019

Bibliographical note

Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and future Planning (NRF-2018R1A2A1A05020683).

Publisher Copyright:
© 2019 The Royal Society of Chemistry.

All Science Journal Classification (ASJC) codes

  • Materials Science (miscellaneous)
  • Environmental Science(all)


Dive into the research topics of 'Plug-and-play safe-by-design production of metal-doped tellurium nanoparticles with safer antimicrobial activities'. Together they form a unique fingerprint.

Cite this