PLGA Core -Shell Nano/Microparticle Delivery System for Biomedical Application

Madhumita Patel, Rajkumar Patel, se min kim

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)


Core–shell particles are very well known for their unique features. Their distinctive inner
core and outer shell structure allowed promising biomedical applications at both nanometer and
micrometer scales. The primary role of core–shell particles is to deliver the loaded drugs as they are
capable of sequence-controlled release and provide protection of drugs. Among other biomedical
polymers, poly (lactic-co-glycolic acid) (PLGA), a food and drug administration (FDA)-approved
polymer, has been recognized for the vehicle material. This review introduces PLGA core–shell
nano/microparticles and summarizes various drug-delivery systems based on these particles for
cancer therapy and tissue regeneration. Tissue regeneration mainly includes bone, cartilage, and
periodontal regeneration.
Original languageEnglish
Issue number3471
Publication statusPublished - 2021 Oct 10


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