Pleomorphic adenocarcinoma of the lacrimal gland with multiple intracranial and spinal metastases

Jung Yong Ahn, Jong Chang, Se Hoon Kim, Kyu Sung Lee

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Background: Pleomorphic adenoma of the lacrimal gland is known to undergo malignant transformation when incompletely excised. Even if such a malignant change occurs, intracranial direct invasion and leptomeningeal seeding are seldom encountered. Case presentation: A 50-year-old woman presented with malignant transformation associated with both intracranial invasion and multiple intracranial and spinal disseminations in the third recurrence of pleomorphic adenoma of the lacrimal gland, 6 years after initial treatment. MRI demonstrated increased extent of orbital mass, extending to the cavernous sinus. The patient underwent intensity-modulated radiation therapy (IMRT) and Gamma Knife radiosurgery. Follow-up MRI showed multiple leptomeningeal disseminations to the intracranium and spine. Conclusion: It is important to recognize that leptomeningeal intracranial and spinal disseminations of pleomorphic adenocarcinoma can occur, although it is extremely rare. To our knowledge, we report the first case of pleomorphic adenocarcinoma of the lacrimal gland presumably metastasizing to the intracranium and spine.

Original languageEnglish
Article number29
JournalWorld Journal of Surgical Oncology
Publication statusPublished - 2007

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology


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