Plasma surface modification of poly (D,L-lactic-co-glycolic acid) (65/35) film for tissue engineering

Gyu Ha Ryu, Won Sun Yang, Hye Won Roh, In Seop Lee, Jeong Koo Kim, Gun Hwan Lee, Dong Hee Lee, Bong Joo Park, Min Sub Lee, Jong Chul Park

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


Plasma technique can easily be used to introduce desired functional groups or chains onto the surface of materials, so it has a special application to improve the cell affinity of scaffolds. Additionally, it has been demonstrated that plasma treatment is a unique and powerful method for modifying polymeric materials without altering their bulk properties. Cell affinity is the most important factor to be considered when biodegradable polymeric materials such as poly (D,L-lactic-co-glycolic acid) (PLGA) are utilized as a cell scaffold in tissue engineering. In this study, PLGA surface was modified with TiO2 using magnetron sputtering in order to improve PLGA surface/cells interaction. The changes of surface properties have been characterized by contact angle measurement and X-ray photoelectron spectroscopy (XPS). To confirm the attachment or proliferation of human dermal fibroblasts and rat cortical neural cells, MTT assay and scanning electron microscopy (SEM) were carried out. The results indicated that TiO2-coated PLGA film became hydrophilic and enhanced cell affinity and/or proliferation. It has been suggested that TiO2 -coated PLGA matrix can be a candidate for cell scaffolds in tissue engineering.

Original languageEnglish
Pages (from-to)60-64
Number of pages5
JournalSurface and Coatings Technology
Issue number1-3 SPEC. ISS.
Publication statusPublished - 2005 Apr 1

Bibliographical note

Funding Information:
This work was supported by Grant No. 02-PJ3-PG3-31402-0018 from the Ministry of Health and Welfare of Korea.

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films
  • Materials Chemistry


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