Plasma free fatty acid level patterns according to cardiovascular risk status in postmenopausal women

Yumie Rhee; Man Jeong Paik; Kyoung Rae Kim; Young Guk Ko; Eun Seok Kang; Bong Soo Cha; Hyun Chul Lee; Sung Kil Lim

doi:10.1016/j.cca.2008.02.012

Plasma free fatty acid level patterns according to cardiovascular risk status in postmenopausal women

Yumie Rhee, Man Jeong Paik, Kyoung Rae Kim, Young Guk Ko, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee, Sung Kil Lim

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Background: The present study examines changes in the pattern of plasma free polyunsaturated fatty acids (PUFA) according to menopausal status and the existence of diabetes mellitus (DM) or coronary heart disease (CHD) in Korean women. Methods: The participants were as follows; premenopausal women (PRE, n = 20) and postmenopausal women without any known chronic disease (POST, n = 35), with DM (DM, n = 35), or with angiographically proven CHD (CHD, n = 30). Plasma free fatty acids were measured in all participants. Results: Healthy premenopausal women had a higher ratio of ω-3/ω-6 PUFA than postmenopausal women (p = 0.001). As expected, the PRE group had higher docsapentaenoic acid (DPA) and docosahexaenoic acid (DHA) levels (p < 0.05) and lower arachidonic acid levels (p < 0.05) than the POST group. In turn, the healthy POST group had higher levels of DPA and DHA compared to the DM or CHD groups (p < 0.05). There were significant shifts of increased ω-6 and decreased ω-3 among the women, according to each disease. Conclusions: There was a significant relationship between ω-3 and ω-6 PUFA profiles and risk for CHD in women. This metabolic profile of PUFA might be an important surrogate marker in postmenopausal women.

Original language	English
Pages (from-to)	11-16
Number of pages	6
Journal	Clinica Chimica Acta
Volume	392
Issue number	1-2
DOIs	https://doi.org/10.1016/j.cca.2008.02.012
Publication status	Published - 2008 Jun

Bibliographical note

Funding Information:
This work was supported by the Choongwae Research Fund form Korean Medical Women's Association. No financial disclosure to do.

All Science Journal Classification (ASJC) codes

Biochemistry
Clinical Biochemistry
Biochemistry, medical

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cca.2008.02.012

Cite this

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title = "Plasma free fatty acid level patterns according to cardiovascular risk status in postmenopausal women",

abstract = "Background: The present study examines changes in the pattern of plasma free polyunsaturated fatty acids (PUFA) according to menopausal status and the existence of diabetes mellitus (DM) or coronary heart disease (CHD) in Korean women. Methods: The participants were as follows; premenopausal women (PRE, n = 20) and postmenopausal women without any known chronic disease (POST, n = 35), with DM (DM, n = 35), or with angiographically proven CHD (CHD, n = 30). Plasma free fatty acids were measured in all participants. Results: Healthy premenopausal women had a higher ratio of ω-3/ω-6 PUFA than postmenopausal women (p = 0.001). As expected, the PRE group had higher docsapentaenoic acid (DPA) and docosahexaenoic acid (DHA) levels (p < 0.05) and lower arachidonic acid levels (p < 0.05) than the POST group. In turn, the healthy POST group had higher levels of DPA and DHA compared to the DM or CHD groups (p < 0.05). There were significant shifts of increased ω-6 and decreased ω-3 among the women, according to each disease. Conclusions: There was a significant relationship between ω-3 and ω-6 PUFA profiles and risk for CHD in women. This metabolic profile of PUFA might be an important surrogate marker in postmenopausal women.",

author = "Yumie Rhee and Paik, {Man Jeong} and Kim, {Kyoung Rae} and Ko, {Young Guk} and Kang, {Eun Seok} and Cha, {Bong Soo} and Lee, {Hyun Chul} and Lim, {Sung Kil}",

note = "Funding Information: This work was supported by the Choongwae Research Fund form Korean Medical Women's Association. No financial disclosure to do.",

year = "2008",

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doi = "10.1016/j.cca.2008.02.012",

language = "English",

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T1 - Plasma free fatty acid level patterns according to cardiovascular risk status in postmenopausal women

AU - Rhee, Yumie

AU - Paik, Man Jeong

AU - Kim, Kyoung Rae

AU - Ko, Young Guk

AU - Kang, Eun Seok

AU - Cha, Bong Soo

AU - Lee, Hyun Chul

AU - Lim, Sung Kil

N1 - Funding Information: This work was supported by the Choongwae Research Fund form Korean Medical Women's Association. No financial disclosure to do.

PY - 2008/6

Y1 - 2008/6

N2 - Background: The present study examines changes in the pattern of plasma free polyunsaturated fatty acids (PUFA) according to menopausal status and the existence of diabetes mellitus (DM) or coronary heart disease (CHD) in Korean women. Methods: The participants were as follows; premenopausal women (PRE, n = 20) and postmenopausal women without any known chronic disease (POST, n = 35), with DM (DM, n = 35), or with angiographically proven CHD (CHD, n = 30). Plasma free fatty acids were measured in all participants. Results: Healthy premenopausal women had a higher ratio of ω-3/ω-6 PUFA than postmenopausal women (p = 0.001). As expected, the PRE group had higher docsapentaenoic acid (DPA) and docosahexaenoic acid (DHA) levels (p < 0.05) and lower arachidonic acid levels (p < 0.05) than the POST group. In turn, the healthy POST group had higher levels of DPA and DHA compared to the DM or CHD groups (p < 0.05). There were significant shifts of increased ω-6 and decreased ω-3 among the women, according to each disease. Conclusions: There was a significant relationship between ω-3 and ω-6 PUFA profiles and risk for CHD in women. This metabolic profile of PUFA might be an important surrogate marker in postmenopausal women.

AB - Background: The present study examines changes in the pattern of plasma free polyunsaturated fatty acids (PUFA) according to menopausal status and the existence of diabetes mellitus (DM) or coronary heart disease (CHD) in Korean women. Methods: The participants were as follows; premenopausal women (PRE, n = 20) and postmenopausal women without any known chronic disease (POST, n = 35), with DM (DM, n = 35), or with angiographically proven CHD (CHD, n = 30). Plasma free fatty acids were measured in all participants. Results: Healthy premenopausal women had a higher ratio of ω-3/ω-6 PUFA than postmenopausal women (p = 0.001). As expected, the PRE group had higher docsapentaenoic acid (DPA) and docosahexaenoic acid (DHA) levels (p < 0.05) and lower arachidonic acid levels (p < 0.05) than the POST group. In turn, the healthy POST group had higher levels of DPA and DHA compared to the DM or CHD groups (p < 0.05). There were significant shifts of increased ω-6 and decreased ω-3 among the women, according to each disease. Conclusions: There was a significant relationship between ω-3 and ω-6 PUFA profiles and risk for CHD in women. This metabolic profile of PUFA might be an important surrogate marker in postmenopausal women.

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Plasma free fatty acid level patterns according to cardiovascular risk status in postmenopausal women

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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