Physiochemical properties and resorption progress of porcine skin-derived collagen membranes: In vitro and in vivo analysis

Yin Zhe An, You Kyoung Kim, Su Min Lim, Yeong Ku Heo, Mi Kyung Kwon, Jae Kook Cha, Jung Seok Lee, Ui Won Jung, Seong Ho Choi

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


The aim of the present study was to evaluate the physiochemical properties and resorption progress of two cross-linked, porcine skin-derived collagen membranes and compare their features with those of a membrane without cross-linking (Bio-Gide® [BG], Geistlich Biomaterials, Wolhusen, Switzerland). Three porcine skin-derived collagen membranes, dehydrothermally (DHT) cross-linked (experimental), DHT and 1-ethyl-3(3-dimethylaminopropyl)-carbodiimide (DHT/EDC) cross-linked (experimental) and BG were investigated for their morphology, enzyme resistance, and tensile strength in vitro and biodegradation in vivo. DHT and DHT/ EDC membranes exhibited irregular, interconnected macro- and micropores that formed a 3D mesh, whereas BG exhibited individual collagen fibrils interlaced to form coarse collagen strands. In enzyme resistance and tensile strength tests, DHT and DHT/EDC membranes demonstrated good resistance and mechanical properties compared with BG. In vivo, all three membranes were well integrated into the surrounding connective tissue. Thus, the DHT membrane exhibited its potential as a barrier membrane for guided bone and tissue regeneration.

Original languageEnglish
Article numberdmj/2017-065
Pages (from-to)332-340
Number of pages9
JournalDental Materials Journal
Issue number2
Publication statusPublished - 2018

Bibliographical note

Publisher Copyright:
© 2018, Japanese Society for Dental Materials and Devices. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • General Dentistry


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