Peroxisome proliferator di-isodecyl phthalate has no carcinogenic potential in Fischer 344 rats

Wan Seob Cho; Beom Seok Han; Byeongwoo Ahn; Ki Taek Nam; Mina Choi; Sang Yeon Oh; Seung Hee Kim; Jayoung Jeong; Dong Deuk Jang

doi:10.1016/j.toxlet.2008.02.013

Peroxisome proliferator di-isodecyl phthalate has no carcinogenic potential in Fischer 344 rats

Wan Seob Cho, Beom Seok Han, Byeongwoo Ahn, Ki Taek Nam, Mina Choi, Sang Yeon Oh, Seung Hee Kim, Jayoung Jeong, Dong Deuk Jang

BioMedical Science Institute

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Di-isodecyl phthalate (DIDP), a peroxisome proliferator-activated receptor-α activator, is widely used as a plasticizer in the manufacture of polyvinyl chloride (PVC), and ultimately in typical vinyl applications, particularly wire, cable and toys, etc. To examine its carcinogenic potential, DIDP was fed to Fischer 344 rats in the diet at doses of 0, 400, 2000 and 8000 ppm for 2 years. Briefly, significant decreases in the overall survival and body weights, and increases in the relative weights of kidneys and liver were noted in both sexes of the highest dose groups. However, no treatment-related neoplastic lesions were observed in the internal organs, including the liver. Unlike di(2-ethylhexyl) phthalate (DEHP), DIDP failed to maintain the catalase-inducing potential between early and late expressions of catalase protein from western blotting, immunohistochemistry and enzyme activity measurements. These results suggest that the non-carcinogenicity of DIDP in F344 rats was due to its limited potential for peroxisomal proliferating activity.

Original language	English
Pages (from-to)	110-116
Number of pages	7
Journal	Toxicology Letters
Volume	178
Issue number	2
DOIs	https://doi.org/10.1016/j.toxlet.2008.02.013
Publication status	Published - 2008 May 5

Bibliographical note

Funding Information:
This work was supported by grant for the Korea National Toxicology Program from the National Institute of Toxicological Research of Korea Food and Drug Administration.

All Science Journal Classification (ASJC) codes

Toxicology

Access to Document

10.1016/j.toxlet.2008.02.013

Cite this

@article{c8b717578454489693518afdd6ceaec3,

title = "Peroxisome proliferator di-isodecyl phthalate has no carcinogenic potential in Fischer 344 rats",

abstract = "Di-isodecyl phthalate (DIDP), a peroxisome proliferator-activated receptor-α activator, is widely used as a plasticizer in the manufacture of polyvinyl chloride (PVC), and ultimately in typical vinyl applications, particularly wire, cable and toys, etc. To examine its carcinogenic potential, DIDP was fed to Fischer 344 rats in the diet at doses of 0, 400, 2000 and 8000 ppm for 2 years. Briefly, significant decreases in the overall survival and body weights, and increases in the relative weights of kidneys and liver were noted in both sexes of the highest dose groups. However, no treatment-related neoplastic lesions were observed in the internal organs, including the liver. Unlike di(2-ethylhexyl) phthalate (DEHP), DIDP failed to maintain the catalase-inducing potential between early and late expressions of catalase protein from western blotting, immunohistochemistry and enzyme activity measurements. These results suggest that the non-carcinogenicity of DIDP in F344 rats was due to its limited potential for peroxisomal proliferating activity.",

author = "Cho, {Wan Seob} and Han, {Beom Seok} and Byeongwoo Ahn and Nam, {Ki Taek} and Mina Choi and Oh, {Sang Yeon} and Kim, {Seung Hee} and Jayoung Jeong and Jang, {Dong Deuk}",

note = "Funding Information: This work was supported by grant for the Korea National Toxicology Program from the National Institute of Toxicological Research of Korea Food and Drug Administration. ",

year = "2008",

month = may,

day = "5",

doi = "10.1016/j.toxlet.2008.02.013",

language = "English",

volume = "178",

pages = "110--116",

journal = "Toxicology Letters",

issn = "0378-4274",

publisher = "Elsevier BV",

number = "2",

}

TY - JOUR

T1 - Peroxisome proliferator di-isodecyl phthalate has no carcinogenic potential in Fischer 344 rats

AU - Cho, Wan Seob

AU - Han, Beom Seok

AU - Ahn, Byeongwoo

AU - Nam, Ki Taek

AU - Choi, Mina

AU - Oh, Sang Yeon

AU - Kim, Seung Hee

AU - Jeong, Jayoung

AU - Jang, Dong Deuk

N1 - Funding Information: This work was supported by grant for the Korea National Toxicology Program from the National Institute of Toxicological Research of Korea Food and Drug Administration.

PY - 2008/5/5

Y1 - 2008/5/5

N2 - Di-isodecyl phthalate (DIDP), a peroxisome proliferator-activated receptor-α activator, is widely used as a plasticizer in the manufacture of polyvinyl chloride (PVC), and ultimately in typical vinyl applications, particularly wire, cable and toys, etc. To examine its carcinogenic potential, DIDP was fed to Fischer 344 rats in the diet at doses of 0, 400, 2000 and 8000 ppm for 2 years. Briefly, significant decreases in the overall survival and body weights, and increases in the relative weights of kidneys and liver were noted in both sexes of the highest dose groups. However, no treatment-related neoplastic lesions were observed in the internal organs, including the liver. Unlike di(2-ethylhexyl) phthalate (DEHP), DIDP failed to maintain the catalase-inducing potential between early and late expressions of catalase protein from western blotting, immunohistochemistry and enzyme activity measurements. These results suggest that the non-carcinogenicity of DIDP in F344 rats was due to its limited potential for peroxisomal proliferating activity.

AB - Di-isodecyl phthalate (DIDP), a peroxisome proliferator-activated receptor-α activator, is widely used as a plasticizer in the manufacture of polyvinyl chloride (PVC), and ultimately in typical vinyl applications, particularly wire, cable and toys, etc. To examine its carcinogenic potential, DIDP was fed to Fischer 344 rats in the diet at doses of 0, 400, 2000 and 8000 ppm for 2 years. Briefly, significant decreases in the overall survival and body weights, and increases in the relative weights of kidneys and liver were noted in both sexes of the highest dose groups. However, no treatment-related neoplastic lesions were observed in the internal organs, including the liver. Unlike di(2-ethylhexyl) phthalate (DEHP), DIDP failed to maintain the catalase-inducing potential between early and late expressions of catalase protein from western blotting, immunohistochemistry and enzyme activity measurements. These results suggest that the non-carcinogenicity of DIDP in F344 rats was due to its limited potential for peroxisomal proliferating activity.

UR - http://www.scopus.com/inward/record.url?scp=42649086022&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42649086022&partnerID=8YFLogxK

U2 - 10.1016/j.toxlet.2008.02.013

DO - 10.1016/j.toxlet.2008.02.013

M3 - Article

C2 - 18407439

AN - SCOPUS:42649086022

SN - 0378-4274

VL - 178

SP - 110

EP - 116

JO - Toxicology Letters

JF - Toxicology Letters

IS - 2

ER -

Peroxisome proliferator di-isodecyl phthalate has no carcinogenic potential in Fischer 344 rats

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this