TY - JOUR
T1 - Permeability parameters measured with dynamic contrast-enhanced MRI
T2 - Correlation with the extravasation of evans blue in a rat model of transient cerebral ischemia
AU - Choi, Hyun Seok
AU - Ahn, Sung Soo
AU - Shin, Na Young
AU - Kim, Jinna
AU - Kim, Jae Hyung
AU - Lee, Jong Eun
AU - Lee, Hye Yeon
AU - Heo, Ji Hoe
AU - Lee, Seung Koo
N1 - Publisher Copyright:
© 2015 The Korean Society of Radiology.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Objective: The purpose of this study was to correlate permeability parameters measured with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using a clinical 3-tesla scanner with extravasation of Evans blue in a rat model with transient cerebral ischemia. Materials and Methods: Sprague-Dawley rats (n = 13) with transient middle cerebral artery occlusion were imaged using a 3-tesla MRI with an 8-channel wrist coil. DCE-MRI was performed 12 hours, 18 hours, and 36 hours after reperfusion. Permeability parameters (Ktrans, ve, and vp) from DCE-MRI were calculated. Evans blue was injected after DCE-MRI and extravasation of Evans blue was correlated as a reference with the integrity of the blood-brain barrier. Correlation analysis was performed between permeability parameters and the extravasation of Evans blue. Results: All permeability parameters (Ktrans, ve, and vp) showed a linear correlation with extravasation of Evans blue. Among them, Ktrans showed highest values of both the correlation coefficient and the coefficient of determination (0.687 and 0.473 respectively, p < 0.001). Conclusion: Permeability parameters obtained by DCE-MRI at 3-T are well-correlated with Evans blue extravasation, and Ktrans shows the strongest correlation among the tested parameters.
AB - Objective: The purpose of this study was to correlate permeability parameters measured with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using a clinical 3-tesla scanner with extravasation of Evans blue in a rat model with transient cerebral ischemia. Materials and Methods: Sprague-Dawley rats (n = 13) with transient middle cerebral artery occlusion were imaged using a 3-tesla MRI with an 8-channel wrist coil. DCE-MRI was performed 12 hours, 18 hours, and 36 hours after reperfusion. Permeability parameters (Ktrans, ve, and vp) from DCE-MRI were calculated. Evans blue was injected after DCE-MRI and extravasation of Evans blue was correlated as a reference with the integrity of the blood-brain barrier. Correlation analysis was performed between permeability parameters and the extravasation of Evans blue. Results: All permeability parameters (Ktrans, ve, and vp) showed a linear correlation with extravasation of Evans blue. Among them, Ktrans showed highest values of both the correlation coefficient and the coefficient of determination (0.687 and 0.473 respectively, p < 0.001). Conclusion: Permeability parameters obtained by DCE-MRI at 3-T are well-correlated with Evans blue extravasation, and Ktrans shows the strongest correlation among the tested parameters.
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U2 - 10.3348/kjr.2015.16.4.791
DO - 10.3348/kjr.2015.16.4.791
M3 - Article
C2 - 26175578
AN - SCOPUS:84939548672
SN - 1229-6929
VL - 16
SP - 791
EP - 797
JO - Korean Journal of Radiology
JF - Korean Journal of Radiology
IS - 4
ER -