Peripheral vasculature in portal hypertension

Seong Hee Kang, Soon Koo Baik

Research output: Chapter in Book/Report/Conference proceedingChapter


Peripheral vasculature in portal hypertension is characterized by hyperdynamic circulation, decreased effective circulating volume, the peripheral venous ‘sump’ effect, and arterial splenic vasodilation. Also, the autonomic nervous system plays a key role in modulation of vasomotor activity. Pathogenetic mechanisms associated with hyperdynamic circulation are known as nitric oxide, endocannabinoids, humoral agents, bile acids, central neural activation, and inflammation. Several studies have reported strategies to reverse the abnormal change of peripheral vasculature in patients with portal hypertension.

Original languageEnglish
Title of host publicationCardio-Hepatology
Subtitle of host publicationConnections Between Hepatic and Cardiovascular Disease
Number of pages14
ISBN (Electronic)9780128173947
ISBN (Print)9780128173954
Publication statusPublished - 2022 Jan 1

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Inc. All rights reserved.

All Science Journal Classification (ASJC) codes

  • General Agricultural and Biological Sciences
  • General Biochemistry,Genetics and Molecular Biology


Dive into the research topics of 'Peripheral vasculature in portal hypertension'. Together they form a unique fingerprint.

Cite this