Paroxetine hydrochloride controlled release POLYOX® matrix tablets: Screening of formulation variables using Plackett-Burman screening design

Shun Ji Jin; Yeon Hee Yoo; Min Soo Kim; Jeong Soo Kim; Jeong Sook Park; Sung Joo Hwang

doi:10.1007/s12272-001-1170-0

Paroxetine hydrochloride controlled release POLYOX® matrix tablets: Screening of formulation variables using Plackett-Burman screening design

Shun Ji Jin, Yeon Hee Yoo, Min Soo Kim, Jeong Soo Kim, Jeong Sook Park, Sung Joo Hwang

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The aim of the present study was to screen the effects of the formulation variables - POLYOX® molecular weight (X₁), the ratio of POLYOX®/Avicel® PH102 (X₂) and the amount of POLYOX® and Avicel® PH102 (X₃), hardness (X₄), HPMCP amount (X₅), Eudragit® L100 amount (X₆), and citric acid amount (X₇) - on the paroxetine hydrochloride release from POLYOX® matrix tablet using the Plackett-Burman screening design. Paroxetine hydrochloride matrix tablets were prepared according to a 7-factor-12-run statistical model and subjected to a 8-h dissolution study in Tris buffer at pH 7.5. The regression results showed that POLYOX® molecular weight (X ₁) and POLYOX®/Avicel® PH102 ratio (X₂) had significantly influence on the drug release mechanism and drug release rate as main effects. Hardness (X₄) had an insignificant effect on the drug release mechanism but a significant effect on the drug release rate. On the other hand, HPMCP, Eudragit® L100 and citric acid had an insignificant effect on the both responses. The information obtained by screening design study can be expected to be useful for further formulation studies.

Original language	English
Pages (from-to)	399-405
Number of pages	7
Journal	Archives of pharmacal research
Volume	31
Issue number	3
DOIs	https://doi.org/10.1007/s12272-001-1170-0
Publication status	Published - 2008 Mar

Bibliographical note

Funding Information:
This study was financially supported by research fund of Chungnam National University in 2007.

All Science Journal Classification (ASJC) codes

Molecular Medicine
Drug Discovery
Organic Chemistry

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10.1007/s12272-001-1170-0

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title = "Paroxetine hydrochloride controlled release POLYOX{\textregistered} matrix tablets: Screening of formulation variables using Plackett-Burman screening design",

abstract = "The aim of the present study was to screen the effects of the formulation variables - POLYOX{\textregistered} molecular weight (X1), the ratio of POLYOX{\textregistered}/Avicel{\textregistered} PH102 (X2) and the amount of POLYOX{\textregistered} and Avicel{\textregistered} PH102 (X3), hardness (X4), HPMCP amount (X5), Eudragit{\textregistered} L100 amount (X6), and citric acid amount (X7) - on the paroxetine hydrochloride release from POLYOX{\textregistered} matrix tablet using the Plackett-Burman screening design. Paroxetine hydrochloride matrix tablets were prepared according to a 7-factor-12-run statistical model and subjected to a 8-h dissolution study in Tris buffer at pH 7.5. The regression results showed that POLYOX{\textregistered} molecular weight (X 1) and POLYOX{\textregistered}/Avicel{\textregistered} PH102 ratio (X2) had significantly influence on the drug release mechanism and drug release rate as main effects. Hardness (X4) had an insignificant effect on the drug release mechanism but a significant effect on the drug release rate. On the other hand, HPMCP, Eudragit{\textregistered} L100 and citric acid had an insignificant effect on the both responses. The information obtained by screening design study can be expected to be useful for further formulation studies.",

author = "Jin, {Shun Ji} and Yoo, {Yeon Hee} and Kim, {Min Soo} and Kim, {Jeong Soo} and Park, {Jeong Sook} and Hwang, {Sung Joo}",

note = "Funding Information: This study was financially supported by research fund of Chungnam National University in 2007.",

year = "2008",

month = mar,

doi = "10.1007/s12272-001-1170-0",

language = "English",

volume = "31",

pages = "399--405",

journal = "Archives of pharmacal research",

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T1 - Paroxetine hydrochloride controlled release POLYOX® matrix tablets

T2 - Screening of formulation variables using Plackett-Burman screening design

AU - Jin, Shun Ji

AU - Yoo, Yeon Hee

AU - Kim, Min Soo

AU - Kim, Jeong Soo

AU - Park, Jeong Sook

AU - Hwang, Sung Joo

N1 - Funding Information: This study was financially supported by research fund of Chungnam National University in 2007.

PY - 2008/3

Y1 - 2008/3

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AB - The aim of the present study was to screen the effects of the formulation variables - POLYOX® molecular weight (X1), the ratio of POLYOX®/Avicel® PH102 (X2) and the amount of POLYOX® and Avicel® PH102 (X3), hardness (X4), HPMCP amount (X5), Eudragit® L100 amount (X6), and citric acid amount (X7) - on the paroxetine hydrochloride release from POLYOX® matrix tablet using the Plackett-Burman screening design. Paroxetine hydrochloride matrix tablets were prepared according to a 7-factor-12-run statistical model and subjected to a 8-h dissolution study in Tris buffer at pH 7.5. The regression results showed that POLYOX® molecular weight (X 1) and POLYOX®/Avicel® PH102 ratio (X2) had significantly influence on the drug release mechanism and drug release rate as main effects. Hardness (X4) had an insignificant effect on the drug release mechanism but a significant effect on the drug release rate. On the other hand, HPMCP, Eudragit® L100 and citric acid had an insignificant effect on the both responses. The information obtained by screening design study can be expected to be useful for further formulation studies.

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Paroxetine hydrochloride controlled release POLYOX® matrix tablets: Screening of formulation variables using Plackett-Burman screening design

Abstract

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