Palladium-catalyzed α-arylation of aryloxyketones for the synthesis of 2,3-Disubstituted benzofurans

Jin Ho Lee; Myungock Kim; Ikyon Kim

doi:10.1021/jo500885w

Palladium-catalyzed α-arylation of aryloxyketones for the synthesis of 2,3-Disubstituted benzofurans

Jin Ho Lee, Myungock Kim, Ikyon Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

A highly efficient palladium-catalyzed α-arylation of aryloxyketones has been developed, allowing for facile installation of various (hetero)aryl groups at C2 position in good to excellent yields. Subsequent cyclodehydration of the resulting α-arylated aryloxyketones provided rapid access to diverse 2,3-disubstitured benzofurans.

Original language	English
Pages (from-to)	6153-6163
Number of pages	11
Journal	Journal of Organic Chemistry
Volume	79
Issue number	13
DOIs	https://doi.org/10.1021/jo500885w
Publication status	Published - 2014 Jul 3

All Science Journal Classification (ASJC) codes

Organic Chemistry

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10.1021/jo500885w

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abstract = "A highly efficient palladium-catalyzed α-arylation of aryloxyketones has been developed, allowing for facile installation of various (hetero)aryl groups at C2 position in good to excellent yields. Subsequent cyclodehydration of the resulting α-arylated aryloxyketones provided rapid access to diverse 2,3-disubstitured benzofurans.",

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Palladium-catalyzed α-arylation of aryloxyketones for the synthesis of 2,3-Disubstituted benzofurans

Abstract

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