TY - JOUR
T1 - P110β in the ventromedial hypothalamus regulates glucose and energy metabolism
AU - Fujikawa, Teppei
AU - Choi, Yun Hee
AU - Yang, Dong Joo
AU - Shin, Dong Min
AU - Donato, Jose
AU - Kohno, Daisuke
AU - Lee, Charlotte E.
AU - Elias, Carol F.
AU - Lee, Syann
AU - Kim, Ki Woo
N1 - Publisher Copyright:
© 2019, The Author(s).
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Phosphoinositide 3-kinase (PI3K) signaling in hypothalamic neurons integrates peripheral metabolic cues, including leptin and insulin, to coordinate systemic glucose and energy homeostasis. PI3K is composed of different subunits, each of which has several unique isoforms. However, the role of the PI3K subunits and isoforms in the ventromedial hypothalamus (VMH), a prominent site for the regulation of glucose and energy homeostasis, is unclear. Here we investigated the role of subunit p110β in steroidogenic factor-1 (SF-1) neurons of the VMH in the regulation of metabolism. Our data demonstrate that the deletion of p110β in SF-1 neurons disrupts glucose metabolism, rendering the mice insulin resistant. In addition, the deletion of p110β in SF-1 neurons leads to the whitening of brown adipose tissues and increased susceptibility to diet-induced obesity due to blunted energy expenditure. These results highlight a critical role for p110β in the regulation of glucose and energy homeostasis via VMH neurons.
AB - Phosphoinositide 3-kinase (PI3K) signaling in hypothalamic neurons integrates peripheral metabolic cues, including leptin and insulin, to coordinate systemic glucose and energy homeostasis. PI3K is composed of different subunits, each of which has several unique isoforms. However, the role of the PI3K subunits and isoforms in the ventromedial hypothalamus (VMH), a prominent site for the regulation of glucose and energy homeostasis, is unclear. Here we investigated the role of subunit p110β in steroidogenic factor-1 (SF-1) neurons of the VMH in the regulation of metabolism. Our data demonstrate that the deletion of p110β in SF-1 neurons disrupts glucose metabolism, rendering the mice insulin resistant. In addition, the deletion of p110β in SF-1 neurons leads to the whitening of brown adipose tissues and increased susceptibility to diet-induced obesity due to blunted energy expenditure. These results highlight a critical role for p110β in the regulation of glucose and energy homeostasis via VMH neurons.
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U2 - 10.1038/s12276-019-0249-8
DO - 10.1038/s12276-019-0249-8
M3 - Article
C2 - 31028248
AN - SCOPUS:85064829743
SN - 1226-3613
VL - 51
JO - Experimental and Molecular Medicine
JF - Experimental and Molecular Medicine
IS - 4
M1 - 52
ER -
