Overcoming Depression by Inhibition of Neural Burst Firing

Daesoo Kim; Eunji Cheong; Hee Sup Shin

doi:10.1016/j.neuron.2018.05.032

Overcoming Depression by Inhibition of Neural Burst Firing

Daesoo Kim, Eunji Cheong, Hee Sup Shin

Research output: Contribution to journal › Short survey › peer-review

4 Citations (Scopus)

Abstract

The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine has been found to have rapid and long-lasting antidepressive effects. Two elegant studies from Hailan Hu's laboratory (Cui et al., 2018; Yang et al., 2018) showed that ketamine blocks burst firing of neurons in the lateral habenula (LHb), rapidly relieving symptoms of depression. The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine has been found to have rapid and long-lasting antidepressive effects. Two elegant studies from Hailan Hu's laboratory (Cui et al., 2018; Yang et al., 2018) showed that ketamine blocks burst firing of neurons in the lateral habenula (LHb), rapidly relieving symptoms of depression.

Original language	English
Pages (from-to)	878-879
Number of pages	2
Journal	Neuron
Volume	98
Issue number	5
DOIs	https://doi.org/10.1016/j.neuron.2018.05.032
Publication status	Published - 2018 Jun 6

Bibliographical note

Funding Information:
Support is from the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, & Future Planning ( 2016R1A2B3015167 to D.K.; 2017R1A2B3011098 and 2017M3C7A1023471 to E.C.) and a grant from the Institute for Basic Science ( IBS-R001-D1 to H-S.S).

Funding Information:
Support is from the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, & Future Planning (2016R1A2B3015167 to D.K.; 2017R1A2B3011098 and 2017M3C7A1023471 to E.C.) and a grant from the Institute for Basic Science (IBS-R001-D1 to H-S.S).

Publisher Copyright:
© 2018 Elsevier Inc.

All Science Journal Classification (ASJC) codes

Neuroscience(all)

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10.1016/j.neuron.2018.05.032

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title = "Overcoming Depression by Inhibition of Neural Burst Firing",

abstract = "The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine has been found to have rapid and long-lasting antidepressive effects. Two elegant studies from Hailan Hu's laboratory (Cui et al., 2018; Yang et al., 2018) showed that ketamine blocks burst firing of neurons in the lateral habenula (LHb), rapidly relieving symptoms of depression. The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine has been found to have rapid and long-lasting antidepressive effects. Two elegant studies from Hailan Hu's laboratory (Cui et al., 2018; Yang et al., 2018) showed that ketamine blocks burst firing of neurons in the lateral habenula (LHb), rapidly relieving symptoms of depression.",

author = "Daesoo Kim and Eunji Cheong and Shin, {Hee Sup}",

note = "Funding Information: Support is from the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, & Future Planning ( 2016R1A2B3015167 to D.K.; 2017R1A2B3011098 and 2017M3C7A1023471 to E.C.) and a grant from the Institute for Basic Science ( IBS-R001-D1 to H-S.S). Funding Information: Support is from the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, & Future Planning (2016R1A2B3015167 to D.K.; 2017R1A2B3011098 and 2017M3C7A1023471 to E.C.) and a grant from the Institute for Basic Science (IBS-R001-D1 to H-S.S). Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

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AU - Cheong, Eunji

AU - Shin, Hee Sup

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Overcoming Depression by Inhibition of Neural Burst Firing

Abstract

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