Osteoconductive effects of calcium phosphate glass cement grafts in rabbit calvarial defects

Hyun Chang Lim, Joo Yeon Sohn, Jung Chul Park, Yoo Jung Um, Ui Won Jung, Chang Sung Kim, Yong Keun Lee, Seong Ho Choi

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14 Citations (Scopus)


Calcium phosphate glass (CPG) is well-documented alloplastic bone graft material. The objective of this study was to evaluate the osteoconductive effect of newly developed calcium phosphate glass cement (CPGC) in rabbit calvarial defects. Three circular defects (8 mm diameter) were created on the rabbit calvarium. One defect was filled with biphasic calcium phosphate (BCP group) and one defect was filled with CPGC (CPGC group). The remaining defect was not filled as the control. Histologic and histometric analysis were performed at four and eight weeks following the implantation of materials. One-way ANOVA method was used to evaluated the significance between three groups (p < 0.05). The CPGC group did not show a statistical difference in new bone area compared with the control at all healing periods, but the bone formation rate of CPGC seemed to increase between four and eight weeks. This suggests the bone formation rate of CPGC is initially slow, but increases at a specific time, showing the possibility of greater bone formation with time. The resorption rate of CPGC was greater than BCP. Within the limits of this study, CPGC demonstrated good space maintaining capacity and had an osteoconductive effect, suggesting it could be successfully used to improve bone formation capacity.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Issue number1
Publication statusPublished - 2010 Oct

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering


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