Oral–gut microbiome axis in gastrointestinal disease and cancer

Se Young Park, Byeong Oh Hwang, Mihwa Lim, Seung Ho Ok, Sun Kyoung Lee, Kyung Soo Chun, Kwang Kyun Park, Yinling Hu, Won Yoon Chung, Na Young Song

Research output: Contribution to journalReview articlepeer-review

34 Citations (Scopus)


It is well-known that microbiota dysbiosis is closely associated with numerous diseases in the human body. The oral cavity and gut are the two largest microbial habitats, playing a major role in microbiome-associated diseases. Even though the oral cavity and gut are continuous regions connected through the gastrointestinal tract, the oral and gut microbiome profiles are well-segregated due to the oral–gut barrier. However, the oral microbiota can translocate to the intestinal mucosa in conditions of the oral–gut barrier dysfunction. Inversely, the gut-to-oral microbial transmission occurs as well in inter-and intrapersonal manners. Recently, it has been reported that oral and gut microbiomes interdependently regulate physiological functions and pathological processes. Oral-to-gut and gut-to-oral microbial transmissions can shape and/or reshape the microbial ecosystem in both habitats, eventually modulating pathogenesis of disease. However, the oral–gut microbial interaction in pathogenesis has been underappreciated to date. Here, we will highlight the oral– gut microbiome crosstalk and its implications in the pathogenesis of the gastrointestinal disease and cancer. Better understanding the role of the oral–gut microbiome axis in pathogenesis will be advantageous for precise diagnosis/prognosis and effective treatment.

Original languageEnglish
Article number1748
Issue number7
Publication statusPublished - 2021 Apr 1

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


Dive into the research topics of 'Oral–gut microbiome axis in gastrointestinal disease and cancer'. Together they form a unique fingerprint.

Cite this