Oral absorption of atorvastatin solid dispersion based on cellulose or pyrrolidone derivative polymers

Min Soo Kim; Jeong Soo Kim; Wonkyung Cho; Hee Jun Park; Sung Joo Hwang

doi:10.1016/j.ijbiomac.2013.03.068

Oral absorption of atorvastatin solid dispersion based on cellulose or pyrrolidone derivative polymers

Min Soo Kim, Jeong Soo Kim, Wonkyung Cho, Hee Jun Park, Sung Joo Hwang

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

The objectives of this study were to investigate the effects of hydrophilic polymer on the supersaturation and oral absorption of amorphous atorvastatin calcium. Solid dispersions of atorvastatin calcium were prepared by a supercritical antisolvent (SAS) process. The solid dispersion with polyvinylpyrrolidone vinyl acetate (PVP VA64) achieved a higher degree and extent of supersaturation than the dispersions prepared with water-soluble polymers such as hydroxypropylmethyl cellulose (HPMC) and polyvinylpyrrolidone (PVP K30). The absorption of atorvastatin in rats was markedly increased when atorvastatin was orally administered in a PVP VA64 solid dispersion due to enhanced supersaturation and dissolution properties. Therefore, the oral absorption of atorvastatin calcium increased with the degree of supersaturation of solid dispersions prepared using an SAS process.

Original language	English
Pages (from-to)	138-142
Number of pages	5
Journal	International Journal of Biological Macromolecules
Volume	59
DOIs	https://doi.org/10.1016/j.ijbiomac.2013.03.068
Publication status	Published - 2013 Aug

Bibliographical note

Funding Information:
This work was supported by the Korea Science and Engineering Foundation (KOSEF) through the National Research Lab. Program funded by the Ministry of Science and Technology (No. M10300000301-06J0000-30110 ) and by the Energy Conservation Technology Program ( 2004-E-ID12-P-05-3-010 ).

All Science Journal Classification (ASJC) codes

Structural Biology
Biochemistry
Molecular Biology

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10.1016/j.ijbiomac.2013.03.068

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title = "Oral absorption of atorvastatin solid dispersion based on cellulose or pyrrolidone derivative polymers",

abstract = "The objectives of this study were to investigate the effects of hydrophilic polymer on the supersaturation and oral absorption of amorphous atorvastatin calcium. Solid dispersions of atorvastatin calcium were prepared by a supercritical antisolvent (SAS) process. The solid dispersion with polyvinylpyrrolidone vinyl acetate (PVP VA64) achieved a higher degree and extent of supersaturation than the dispersions prepared with water-soluble polymers such as hydroxypropylmethyl cellulose (HPMC) and polyvinylpyrrolidone (PVP K30). The absorption of atorvastatin in rats was markedly increased when atorvastatin was orally administered in a PVP VA64 solid dispersion due to enhanced supersaturation and dissolution properties. Therefore, the oral absorption of atorvastatin calcium increased with the degree of supersaturation of solid dispersions prepared using an SAS process.",

author = "Kim, {Min Soo} and Kim, {Jeong Soo} and Wonkyung Cho and Park, {Hee Jun} and Hwang, {Sung Joo}",

note = "Funding Information: This work was supported by the Korea Science and Engineering Foundation (KOSEF) through the National Research Lab. Program funded by the Ministry of Science and Technology (No. M10300000301-06J0000-30110 ) and by the Energy Conservation Technology Program ( 2004-E-ID12-P-05-3-010 ).",

year = "2013",

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doi = "10.1016/j.ijbiomac.2013.03.068",

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journal = "International Journal of Biological Macromolecules",

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AU - Kim, Min Soo

AU - Kim, Jeong Soo

AU - Cho, Wonkyung

AU - Park, Hee Jun

AU - Hwang, Sung Joo

N1 - Funding Information: This work was supported by the Korea Science and Engineering Foundation (KOSEF) through the National Research Lab. Program funded by the Ministry of Science and Technology (No. M10300000301-06J0000-30110 ) and by the Energy Conservation Technology Program ( 2004-E-ID12-P-05-3-010 ).

PY - 2013/8

Y1 - 2013/8

N2 - The objectives of this study were to investigate the effects of hydrophilic polymer on the supersaturation and oral absorption of amorphous atorvastatin calcium. Solid dispersions of atorvastatin calcium were prepared by a supercritical antisolvent (SAS) process. The solid dispersion with polyvinylpyrrolidone vinyl acetate (PVP VA64) achieved a higher degree and extent of supersaturation than the dispersions prepared with water-soluble polymers such as hydroxypropylmethyl cellulose (HPMC) and polyvinylpyrrolidone (PVP K30). The absorption of atorvastatin in rats was markedly increased when atorvastatin was orally administered in a PVP VA64 solid dispersion due to enhanced supersaturation and dissolution properties. Therefore, the oral absorption of atorvastatin calcium increased with the degree of supersaturation of solid dispersions prepared using an SAS process.

AB - The objectives of this study were to investigate the effects of hydrophilic polymer on the supersaturation and oral absorption of amorphous atorvastatin calcium. Solid dispersions of atorvastatin calcium were prepared by a supercritical antisolvent (SAS) process. The solid dispersion with polyvinylpyrrolidone vinyl acetate (PVP VA64) achieved a higher degree and extent of supersaturation than the dispersions prepared with water-soluble polymers such as hydroxypropylmethyl cellulose (HPMC) and polyvinylpyrrolidone (PVP K30). The absorption of atorvastatin in rats was markedly increased when atorvastatin was orally administered in a PVP VA64 solid dispersion due to enhanced supersaturation and dissolution properties. Therefore, the oral absorption of atorvastatin calcium increased with the degree of supersaturation of solid dispersions prepared using an SAS process.

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JO - International Journal of Biological Macromolecules

JF - International Journal of Biological Macromolecules

ER -

Oral absorption of atorvastatin solid dispersion based on cellulose or pyrrolidone derivative polymers

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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