TY - JOUR
T1 - Orai1 and STIM1 in ER/PM junctions
T2 - Roles in pancreatic cell function and dysfunction
AU - Son, Aran
AU - Park, Seonghee
AU - Shin, Dong Min
AU - Muallem, Shmuel
N1 - Publisher Copyright:
© 2016 the American Physiological Society.
PY - 2016/3/15
Y1 - 2016/3/15
N2 - Membrane contact sites (MCS) are critical junctions that form between the endoplasmic reticulum (ER) and membranes of various organelles, including the plasma membrane (PM). Signaling complexes, including mediators of Ca2+ signaling, are assembled within MCS, such as the ER/PM junction. This is most evident in polarized epithelial cells, such as pancreatic cells. Core Ca2+ signaling proteins cluster at the apical pole, the site of inositol 1,4,5-trisphosphate-mediated Ca2+ release and Orai1/transient receptor potential canonical-mediated store-dependent Ca2+ entry. Recent advances have characterized the proteins that tether the membranes at MCS and the role of these proteins in modulating physiological and pathological intracellular signaling. This review discusses recent advances in the characterization of Ca2+ signaling at ER/PM junctions and the relation of these junctions to physiological and pathological Ca2+ signaling in pancreatic acini.
AB - Membrane contact sites (MCS) are critical junctions that form between the endoplasmic reticulum (ER) and membranes of various organelles, including the plasma membrane (PM). Signaling complexes, including mediators of Ca2+ signaling, are assembled within MCS, such as the ER/PM junction. This is most evident in polarized epithelial cells, such as pancreatic cells. Core Ca2+ signaling proteins cluster at the apical pole, the site of inositol 1,4,5-trisphosphate-mediated Ca2+ release and Orai1/transient receptor potential canonical-mediated store-dependent Ca2+ entry. Recent advances have characterized the proteins that tether the membranes at MCS and the role of these proteins in modulating physiological and pathological intracellular signaling. This review discusses recent advances in the characterization of Ca2+ signaling at ER/PM junctions and the relation of these junctions to physiological and pathological Ca2+ signaling in pancreatic acini.
KW - ER
KW - Junctions
KW - PM
KW - Pancreas
KW - Signaling
UR - http://www.scopus.com/inward/record.url?scp=84981204888&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84981204888&partnerID=8YFLogxK
U2 - 10.1152/ajpcell.00349.2015
DO - 10.1152/ajpcell.00349.2015
M3 - Article
C2 - 26739495
AN - SCOPUS:84981204888
SN - 0363-6143
VL - 310
SP - C414-C422
JO - American Journal of Physiology - Cell Physiology
JF - American Journal of Physiology - Cell Physiology
IS - 6
ER -