Orai1 and STIM1 in ER/PM junctions: Roles in pancreatic cell function and dysfunction

Aran Son; Seonghee Park; Dong Min Shin; Shmuel Muallem

doi:10.1152/ajpcell.00349.2015

Orai1 and STIM1 in ER/PM junctions: Roles in pancreatic cell function and dysfunction

Aran Son, Seonghee Park, Dong Min Shin, Shmuel Muallem

Department of Oral Biology

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Membrane contact sites (MCS) are critical junctions that form between the endoplasmic reticulum (ER) and membranes of various organelles, including the plasma membrane (PM). Signaling complexes, including mediators of Ca²⁺ signaling, are assembled within MCS, such as the ER/PM junction. This is most evident in polarized epithelial cells, such as pancreatic cells. Core Ca²⁺ signaling proteins cluster at the apical pole, the site of inositol 1,4,5-trisphosphate-mediated Ca²⁺ release and Orai1/transient receptor potential canonical-mediated store-dependent Ca²⁺ entry. Recent advances have characterized the proteins that tether the membranes at MCS and the role of these proteins in modulating physiological and pathological intracellular signaling. This review discusses recent advances in the characterization of Ca²⁺ signaling at ER/PM junctions and the relation of these junctions to physiological and pathological Ca²⁺ signaling in pancreatic acini.

Original language	English
Pages (from-to)	C414-C422
Journal	American Journal of Physiology - Cell Physiology
Volume	310
Issue number	6
DOIs	https://doi.org/10.1152/ajpcell.00349.2015
Publication status	Published - 2016 Mar 15

Bibliographical note

Funding Information:
This work was supported by National Institutes of Health/National Institute of Dental and Craniofacial Research intramural grant DE-000735 and by the National Foundation of Korea Grant funded by the Korean Government (NRF-2013S1A2A2035370, 2015R1A2A1A15054157).

Publisher Copyright:
© 2016 the American Physiological Society.

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Physiology
Cell Biology

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10.1152/ajpcell.00349.2015

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title = "Orai1 and STIM1 in ER/PM junctions: Roles in pancreatic cell function and dysfunction",

abstract = "Membrane contact sites (MCS) are critical junctions that form between the endoplasmic reticulum (ER) and membranes of various organelles, including the plasma membrane (PM). Signaling complexes, including mediators of Ca2+ signaling, are assembled within MCS, such as the ER/PM junction. This is most evident in polarized epithelial cells, such as pancreatic cells. Core Ca2+ signaling proteins cluster at the apical pole, the site of inositol 1,4,5-trisphosphate-mediated Ca2+ release and Orai1/transient receptor potential canonical-mediated store-dependent Ca2+ entry. Recent advances have characterized the proteins that tether the membranes at MCS and the role of these proteins in modulating physiological and pathological intracellular signaling. This review discusses recent advances in the characterization of Ca2+ signaling at ER/PM junctions and the relation of these junctions to physiological and pathological Ca2+ signaling in pancreatic acini.",

author = "Aran Son and Seonghee Park and Shin, {Dong Min} and Shmuel Muallem",

note = "Funding Information: This work was supported by National Institutes of Health/National Institute of Dental and Craniofacial Research intramural grant DE-000735 and by the National Foundation of Korea Grant funded by the Korean Government (NRF-2013S1A2A2035370, 2015R1A2A1A15054157). Publisher Copyright: {\textcopyright} 2016 the American Physiological Society.",

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doi = "10.1152/ajpcell.00349.2015",

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AU - Park, Seonghee

AU - Shin, Dong Min

AU - Muallem, Shmuel

N1 - Funding Information: This work was supported by National Institutes of Health/National Institute of Dental and Craniofacial Research intramural grant DE-000735 and by the National Foundation of Korea Grant funded by the Korean Government (NRF-2013S1A2A2035370, 2015R1A2A1A15054157). Publisher Copyright: © 2016 the American Physiological Society.

PY - 2016/3/15

Y1 - 2016/3/15

N2 - Membrane contact sites (MCS) are critical junctions that form between the endoplasmic reticulum (ER) and membranes of various organelles, including the plasma membrane (PM). Signaling complexes, including mediators of Ca2+ signaling, are assembled within MCS, such as the ER/PM junction. This is most evident in polarized epithelial cells, such as pancreatic cells. Core Ca2+ signaling proteins cluster at the apical pole, the site of inositol 1,4,5-trisphosphate-mediated Ca2+ release and Orai1/transient receptor potential canonical-mediated store-dependent Ca2+ entry. Recent advances have characterized the proteins that tether the membranes at MCS and the role of these proteins in modulating physiological and pathological intracellular signaling. This review discusses recent advances in the characterization of Ca2+ signaling at ER/PM junctions and the relation of these junctions to physiological and pathological Ca2+ signaling in pancreatic acini.

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Orai1 and STIM1 in ER/PM junctions: Roles in pancreatic cell function and dysfunction

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