Optimal timing of [18F]Mefway PET for imaging the serotonin 1A receptor in healthy male subjects

Jae Hoon Lee; Young Hoon Ryu; Chul Hyoung Lyoo; Soo Hee Choi; Jae Jin Kim; Jae Yong Choi

doi:10.1016/j.apradiso.2015.10.004

Optimal timing of [¹⁸F]Mefway PET for imaging the serotonin 1A receptor in healthy male subjects

Jae Hoon Lee, Young Hoon Ryu, Chul Hyoung Lyoo, Soo Hee Choi, Jae Jin Kim, Jae Yong Choi

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

To determine the optimal acquisition time of [¹⁸F]Mefway PET, we examined the regional specific-to-nonspecific binding ratios and evaluated the relationship between distribution volume ratios (DVRs) and standardized uptake value ratios (SUVRs) in various time windows. The specific-to-nonspecific binding ratios peaked after 40min and there was a strong correlation between DVR and SUVR in the 60-80min. Therefore, we recommend the use of a single time point between 60 and 80min for [¹⁸F]Mefway static PET.

Original language	English
Pages (from-to)	127-132
Number of pages	6
Journal	Applied Radiation and Isotopes
Volume	107
DOIs	https://doi.org/10.1016/j.apradiso.2015.10.004
Publication status	Published - 2016 Jan 1

Bibliographical note

Funding Information:
This study was supported by a 2014 faculty research Grant from Yonsei University College of Medicine ( 6-2014-0030 ).

Publisher Copyright:
© 2015 Elsevier Ltd.

All Science Journal Classification (ASJC) codes

Radiation

Access to Document

10.1016/j.apradiso.2015.10.004

Cite this

@article{6803b6c1e5764c549a4a2ead8e187403,

title = "Optimal timing of [18F]Mefway PET for imaging the serotonin 1A receptor in healthy male subjects",

abstract = "To determine the optimal acquisition time of [18F]Mefway PET, we examined the regional specific-to-nonspecific binding ratios and evaluated the relationship between distribution volume ratios (DVRs) and standardized uptake value ratios (SUVRs) in various time windows. The specific-to-nonspecific binding ratios peaked after 40min and there was a strong correlation between DVR and SUVR in the 60-80min. Therefore, we recommend the use of a single time point between 60 and 80min for [18F]Mefway static PET.",

author = "Lee, {Jae Hoon} and Ryu, {Young Hoon} and Lyoo, {Chul Hyoung} and Choi, {Soo Hee} and Kim, {Jae Jin} and Choi, {Jae Yong}",

note = "Funding Information: This study was supported by a 2014 faculty research Grant from Yonsei University College of Medicine ( 6-2014-0030 ). Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2016",

month = jan,

day = "1",

doi = "10.1016/j.apradiso.2015.10.004",

language = "English",

volume = "107",

pages = "127--132",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Optimal timing of [18F]Mefway PET for imaging the serotonin 1A receptor in healthy male subjects

AU - Lee, Jae Hoon

AU - Ryu, Young Hoon

AU - Lyoo, Chul Hyoung

AU - Choi, Soo Hee

AU - Kim, Jae Jin

AU - Choi, Jae Yong

PY - 2016/1/1

Y1 - 2016/1/1

N2 - To determine the optimal acquisition time of [18F]Mefway PET, we examined the regional specific-to-nonspecific binding ratios and evaluated the relationship between distribution volume ratios (DVRs) and standardized uptake value ratios (SUVRs) in various time windows. The specific-to-nonspecific binding ratios peaked after 40min and there was a strong correlation between DVR and SUVR in the 60-80min. Therefore, we recommend the use of a single time point between 60 and 80min for [18F]Mefway static PET.

AB - To determine the optimal acquisition time of [18F]Mefway PET, we examined the regional specific-to-nonspecific binding ratios and evaluated the relationship between distribution volume ratios (DVRs) and standardized uptake value ratios (SUVRs) in various time windows. The specific-to-nonspecific binding ratios peaked after 40min and there was a strong correlation between DVR and SUVR in the 60-80min. Therefore, we recommend the use of a single time point between 60 and 80min for [18F]Mefway static PET.

UR - http://www.scopus.com/inward/record.url?scp=84944810394&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944810394&partnerID=8YFLogxK

U2 - 10.1016/j.apradiso.2015.10.004

DO - 10.1016/j.apradiso.2015.10.004

M3 - Article

C2 - 26492323

AN - SCOPUS:84944810394

SN - 0969-8043

VL - 107

SP - 127

EP - 132

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

ER -