Optical coherence evaluation of everolimus-eluting stents 8 months after implantation

Takumi Inoue, Junya Shite, Junghan Yoon, Toshiro Shinke, Hiromasa Otake, Takahiro Sawada, Hiroyuki Kawamori, Hiroki Katoh, Naoki Miyoshi, Naoki Yoshino, Amane Kozuki, Hirotoshi Hariki, Ken Ichi Hirata

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)


Objective: The aim of this study was to evaluate detailed vessel response after everolimus-eluting stents (EES) implantation in human de novo coronary lesions by optical coherence tomography (OCT). Design, setting and patients: Between November 2008 and October 2009, 25 patients (14 men, 65.568.6 years) with de novo native coronary artery lesions were implanted with 30 EES, and OCT was performed at 8 months post-implantation. Main outcome measures: Neointimal thickness (NIT) on each strut, strut apposition to the vessel wall, the frequency of struts surrounded by low intensity area and the incidence of intra-stent thrombus were analysed. To evaluate the radial unevenness of NIT, the difference between the maximum and minimum NIT (dNT) was calculated for each cross-section. Results: At 236±39 days after implantation, there were no major adverse cardiac events, nor target vessel revascularisation. A total of 5931 struts was evaluated by OCT. The median NIT was 80 μm (25th and 75th percentile 50 μm and 140 mm) and average NIT was 100±74 μm. The number of neointima-covered struts was 5834 (98.4%), and 31 (0.52%) struts showed malapposition without neointimal coverage. The number of struts surrounded by low intensity area was 452 (7.62%). Eleven EES (37%) showed full neointimal coverage. No intra-stent thrombus was detected. The average dNT was 108±77 mm. Conclusions: Most EES struts were covered with uniform and thin neointima. The frequency of low-intensity neointima was very low, which may be a result of promoted vessel healing. These results may support improved clinical outcomes with EES in clinical trials.

Original languageEnglish
Pages (from-to)1379-1384
Number of pages6
Issue number17
Publication statusPublished - 2011 Sept

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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