Optical analysis of homocysteine metabolites using vibrational spectroscopy

Mingzhou Chen; Lisa Strother; Gayle H. Doherty; Kishan Dholakia

doi:10.1364/OSAC.397780

Optical analysis of homocysteine metabolites using vibrational spectroscopy

Mingzhou Chen, Lisa Strother, Gayle H. Doherty, Kishan Dholakia

Department of Physics

Research output: Contribution to journal › Article › peer-review

Abstract

Homocysteine (HCy) is a sulphur-containing amino acid that correlates with several maladaptive health conditions, including an enhanced risk of cardiovascular and neurodegenerative diseases. Detection of HCy and its potentially pathogenic metabolites are studied here for the first time, to the first of our knowledge, using Raman spectroscopy. This study shows that different HCy metabolites have distinct Raman spectra and that the limits of detection reach the sub-mM level for these compounds. This investigation paves the way for photonics–based approaches for detection of HCy–related fluids as predictive biomarkers of disease in blood, which would assist in early intervention for improved clinical outcomes.

Original language	English
Pages (from-to)	1958-1966
Number of pages	9
Journal	OSA Continuum
Volume	3
Issue number	7
DOIs	https://doi.org/10.1364/OSAC.397780
Publication status	Published - 2020 Jul 15

Bibliographical note

Publisher Copyright:
© 2020 OSA - The Optical Society. All rights reserved.

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Electrical and Electronic Engineering

Access to Document

10.1364/OSAC.397780

Cite this

@article{d95dd068db4e462aaeb507bd6ae69a6d,

title = "Optical analysis of homocysteine metabolites using vibrational spectroscopy",

abstract = "Homocysteine (HCy) is a sulphur-containing amino acid that correlates with several maladaptive health conditions, including an enhanced risk of cardiovascular and neurodegenerative diseases. Detection of HCy and its potentially pathogenic metabolites are studied here for the first time, to the first of our knowledge, using Raman spectroscopy. This study shows that different HCy metabolites have distinct Raman spectra and that the limits of detection reach the sub-mM level for these compounds. This investigation paves the way for photonics–based approaches for detection of HCy–related fluids as predictive biomarkers of disease in blood, which would assist in early intervention for improved clinical outcomes.",

author = "Mingzhou Chen and Lisa Strother and Doherty, {Gayle H.} and Kishan Dholakia",

year = "2020",

month = jul,

day = "15",

doi = "10.1364/OSAC.397780",

language = "English",

volume = "3",

pages = "1958--1966",

journal = "OSA Continuum",

issn = "2578-7519",

publisher = "OSA - The Optical Society",

number = "7",

}

TY - JOUR

T1 - Optical analysis of homocysteine metabolites using vibrational spectroscopy

AU - Chen, Mingzhou

AU - Strother, Lisa

AU - Doherty, Gayle H.

AU - Dholakia, Kishan

PY - 2020/7/15

Y1 - 2020/7/15

N2 - Homocysteine (HCy) is a sulphur-containing amino acid that correlates with several maladaptive health conditions, including an enhanced risk of cardiovascular and neurodegenerative diseases. Detection of HCy and its potentially pathogenic metabolites are studied here for the first time, to the first of our knowledge, using Raman spectroscopy. This study shows that different HCy metabolites have distinct Raman spectra and that the limits of detection reach the sub-mM level for these compounds. This investigation paves the way for photonics–based approaches for detection of HCy–related fluids as predictive biomarkers of disease in blood, which would assist in early intervention for improved clinical outcomes.

AB - Homocysteine (HCy) is a sulphur-containing amino acid that correlates with several maladaptive health conditions, including an enhanced risk of cardiovascular and neurodegenerative diseases. Detection of HCy and its potentially pathogenic metabolites are studied here for the first time, to the first of our knowledge, using Raman spectroscopy. This study shows that different HCy metabolites have distinct Raman spectra and that the limits of detection reach the sub-mM level for these compounds. This investigation paves the way for photonics–based approaches for detection of HCy–related fluids as predictive biomarkers of disease in blood, which would assist in early intervention for improved clinical outcomes.

UR - http://www.scopus.com/inward/record.url?scp=85105689161&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85105689161&partnerID=8YFLogxK

U2 - 10.1364/OSAC.397780

DO - 10.1364/OSAC.397780

M3 - Article

AN - SCOPUS:85105689161

SN - 2578-7519

VL - 3

SP - 1958

EP - 1966

JO - OSA Continuum

JF - OSA Continuum

IS - 7

ER -

Optical analysis of homocysteine metabolites using vibrational spectroscopy

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this