Optical analysis of homocysteine metabolites using vibrational spectroscopy

Mingzhou Chen, Lisa Strother, Gayle H. Doherty, Kishan Dholakia

Research output: Contribution to journalArticlepeer-review


Homocysteine (HCy) is a sulphur-containing amino acid that correlates with several maladaptive health conditions, including an enhanced risk of cardiovascular and neurodegenerative diseases. Detection of HCy and its potentially pathogenic metabolites are studied here for the first time, to the first of our knowledge, using Raman spectroscopy. This study shows that different HCy metabolites have distinct Raman spectra and that the limits of detection reach the sub-mM level for these compounds. This investigation paves the way for photonics–based approaches for detection of HCy–related fluids as predictive biomarkers of disease in blood, which would assist in early intervention for improved clinical outcomes.

Original languageEnglish
Pages (from-to)1958-1966
Number of pages9
JournalOSA Continuum
Issue number7
Publication statusPublished - 2020 Jul 15

Bibliographical note

Publisher Copyright:
© 2020 OSA - The Optical Society. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering


Dive into the research topics of 'Optical analysis of homocysteine metabolites using vibrational spectroscopy'. Together they form a unique fingerprint.

Cite this