One-pot, three-component approach to diarylacetonitriles

Dileep Kumar Singh; Sure Siva Prasad; Jinhwang Kim; Ikyon Kim

doi:10.1039/c8qo01419a

One-pot, three-component approach to diarylacetonitriles

Dileep Kumar Singh, Sure Siva Prasad, Jinhwang Kim, Ikyon Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Described herein is a novel one-pot, three-component reaction where aldehydes, electron-rich arenes, and TMSCN in the presence of BF ₃ -OEt ₂ allowed direct access to a number of diarylacetonitriles under mild reaction conditions in good to excellent yields. Implementation of this assembly protocol to a concise synthetic approach to shoreaphenol, a bioactive oligostilbenoid natural product, is also demonstrated.

Original language	English
Pages (from-to)	669-673
Number of pages	5
Journal	Organic Chemistry Frontiers
Volume	6
Issue number	5
DOIs	https://doi.org/10.1039/c8qo01419a
Publication status	Published - 2019 Mar 7

Bibliographical note

Funding Information:
We thank the National Research Foundation of Korea (NRF-2017R1A2A2A05069364 and NRF-2018R1A6A1A03023718) for generous financial support.

Publisher Copyright:
© 2019 the Partner Organisations.

All Science Journal Classification (ASJC) codes

Organic Chemistry

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10.1039/c8qo01419a

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abstract = " Described herein is a novel one-pot, three-component reaction where aldehydes, electron-rich arenes, and TMSCN in the presence of BF 3 -OEt 2 allowed direct access to a number of diarylacetonitriles under mild reaction conditions in good to excellent yields. Implementation of this assembly protocol to a concise synthetic approach to shoreaphenol, a bioactive oligostilbenoid natural product, is also demonstrated.",

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note = "Funding Information: We thank the National Research Foundation of Korea (NRF-2017R1A2A2A05069364 and NRF-2018R1A6A1A03023718) for generous financial support. Publisher Copyright: {\textcopyright} 2019 the Partner Organisations.",

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AU - Singh, Dileep Kumar

AU - Prasad, Sure Siva

AU - Kim, Jinhwang

AU - Kim, Ikyon

N1 - Funding Information: We thank the National Research Foundation of Korea (NRF-2017R1A2A2A05069364 and NRF-2018R1A6A1A03023718) for generous financial support. Publisher Copyright: © 2019 the Partner Organisations.

PY - 2019/3/7

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N2 - Described herein is a novel one-pot, three-component reaction where aldehydes, electron-rich arenes, and TMSCN in the presence of BF 3 -OEt 2 allowed direct access to a number of diarylacetonitriles under mild reaction conditions in good to excellent yields. Implementation of this assembly protocol to a concise synthetic approach to shoreaphenol, a bioactive oligostilbenoid natural product, is also demonstrated.

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One-pot, three-component approach to diarylacetonitriles

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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