One-pot synthesis of hyperbranched polyamines based on novel amino glycidyl ether

We report a one-pot synthesis of hyperbranched polyglycerols possessing amino functionality by using a novel Boc-protected aminoethanol glycidyl ether monomer (BAG). A series of hyperbranched Boc-protected polyamino glycerols (PBAG) were prepared through a one-pot anionic ring opening multibranching polymerization to yield PBAG with controlled molecular weights (3500–17400 g/mol). Subsequent deprotection of PBAG yielded hyperbranched polyamino glycerols (PAG) with a globular polymeric structure that comprises a randomly branched structure with a large number of functional amine and hydroxyl groups. ¹H, ¹³C, and ¹⁵N-NMR, GPC, and MALDI-TOF measurements confirmed the successful polymerization of the hyperbranched PAG polymers. With its superior biocompatibility of PAG, we anticipate the prospective potentials for the applications in biological and biomedical fields.