One-pot synthesis of conjugated alkynenitriles from aldehydes

Joong Gon Kim, Eun Hwa Lee, Doo Ok Jang

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


A method of preparing conjugated alkynenitriles was developed from various aldehydes with CCl3CN and PPh3 in the presence of tBuLi. The reaction proceeded via α-chlorovinyl nitrile as an intermediate without any side reactions such as chlorination of starting aldehydes.

Original languageEnglish
Pages (from-to)2299-2301
Number of pages3
JournalTetrahedron Letters
Issue number13
Publication statusPublished - 2007 Mar 26

Bibliographical note

Funding Information:
This work was supported by Center for Bioactive Molecular Hybrids at Yonsei University.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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